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Product name : Nelarabine (Arranon)
Item : cc156
Price : 200mg, $459;500mg, $850; 1g $1195; 2g, $1795
contact : Send inquiry to: info@acesobio.com,or by fax to: 1-845-673-1239.
CAS : 121032-29-9
Molecular Weight : 297.27
Formula : C₁₁H₁₅N₅O₅
Storage : at -20°C
Additional information : We offer significant discount for bulky quantity order
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Details:
Nelarabine (Arranon, 506U78) is a purine nucleoside analog and DNA synthesis inhibitor for HSB2 cell lines and ALL-SIL cell lines with IC50 of 0.13 μg/mL and 0.37 μg/mL, respectively. Nelarabine is demethoxylated by adenosine deaminase to become biologically active 9-beta-D-arabinosylguanine (ara-G); ara-G incorporates into DNA, thereby inhibiting DNA synthesis and inducing an S phase-dependent apoptosis of tumor cells.  [1][2]
 
Reference:
[1] J Haematol. 2007, 137, 109-116.
[2] Blood 2007, 109, 5136-5142.
 
 
Chemical Information
Molecular Weight (WM):
297.27
Formula:
C11H15N5O5
CAS No:
121032-29-9
Purity:
≥ 98%
Synonyms:
Arranon
 
DMSO ≥ 60 mg/mL
Solubility (25℃)
Water ≥ 5 mg/mL
 
Ethanol < 1 mg/mL
 
2 years     -20℃        Powder
Stability:
2 weeks     -4℃        in DMSO
 
2 months    -80℃       in DMSO
 
Quality control data:
Quality control by 1H-NMR, 13C-NMR, HPLC and LCMS.
Product will be shipped with supporting analytical data.
 
PLEASE KEEP THE PRODUCT UNDER -20℃ FOR LONG-TERM STORAGE.
 
NOT FOR HUMAN OR VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.

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