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Product name : LDN 193189
Item : cc233
Price : 200mg, $750;500mg, $1190; 1g $1890; 2g, $2995
contact : Send inquiry to: info@acesobio.com,or by fax to: 1-845-673-1239.
CAS : 1062368-62-0
Molecular Weight : 552.33
Formula : C₂₅H₂₆Cl₄N₆
Storage : at -20°C
Additional information : We offer significant discount for bulky quantity order
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Details:
LDN-193189 is a cell permeable small molecule inhibitor of bone morphogenetic protein (BMP) type I receptors ALK2 and ALK3 (IC50 = 5 nM and 30 nM respectively). LDN193189 was derived from structure-activity relationship studies of Dorsomorphin and functions primarily through prevention of Smad1, Smad5, and Smad8 phosphorylation. LDN 93189 only weakly inhibits ALK4, ALK5, and ALK7. BMP signaling coordinates developmental patterning and has essential physiological roles in mature organisms. LDN-193189  has been used to reduce ectopic ossification in a mouse model of fibrodysplasia ossificans progressiva.   [1][2]
 
Reference:
[1] Nat. Med. 2008, 14, 1363-1369.
[2] Nat. Chem. Biol. 2008, 4, 33-41.
 
 
Chemical Information
Molecular Weight (WM):
406.48
Formula:
C25H22N6
CAS No:
1062368-24-4, 1062368-62-0 (HCl)
Purity:
≥ 98%
Synonyms:
LDN 93189
 
DMSO ≥ 4 mg/mL
Solubility (25℃)
Water ≥ 30 mg/mL
 
Ethanol < 1 mg/mL
 
2 years     -20℃       Powder
Stability:
2 weeks     -4℃        in DMSO
 
2 months    -80℃       in DMSO
 
Quality control data:
Quality control by 1H-NMR, 13C-NMR, HPLC and LCMS.
Product will be shipped with supporting analytical data.
 
PLEASE KEEP THE PRODUCT UNDER -20℃ FOR LONG-TERM STORAGE.
 
NOT FOR HUMAN OR VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.

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