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Product name : PLX 4720
Item : cc-4
Price : 10mg/$120; 25mg/$195; 50mg/$450, 100mg/$595
contact : Send enquiry to: info@acesobio.com,or by fax to: 1-845-673-1239.
Additional Information : We offer significant discount for larger quantity order
CAS : 918505-84-7
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Details:
PLX 4720, developed by Plexxikon, Inc., is a 7-azaindole derivative that inhibits B-Raf (V600E) with an IC50 of 13 nM, defines a class of kinase inhibitor with marked selectivity in both biochemical and cellular assays. PlX 4720 preferentially inhibits the active B-Raf (V600E) kinase compared with a broad spectrum of other kinases, and potent cytotoxic effects are also exclusive to cells bearing the V600E allele. [1][2]
 
Reference:
[1] Nature, 2010, 464(7287), 427-430.
[2] Nature, 2010, 464(7287), 431-435.
 
                                          
Chemical Information
Molecular Weight (WM):
413.04
Formula:
C17H14ClF2N3O3S
CAS No:
918505-84-7
Purity:
≥ 98%
Synonyms:
PLX-4720
 
DMSO ≥ 83 mg/mL
Solubility: (R.T.: 25℃):
Water < 1 mg/mL
 
Ethanol < 1 mg/mL
 
2 years     -20℃        Powder
Stability:
2 weeks     -4℃        in DMSO
 
2 months    -80℃       in DMSO
 
Quality control data:
Quality control by 1H-NMR, 13C-NMR, HPLC and LCMS.
Product will be shipped with supporting analytical data.
 
PLEASE KEEP THE PRODUCT UNDER -20℃ FOR LONG-TERM STORAGE.
 
NOT FOR HUMAN OR VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.
 

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