Favorite  |  Set Home
Products > MAPK > Raf > PLX 4720
Product name : PLX 4720
Item : cc-4
Price : 200mg, $659;500mg, $1050; 1g $1595; 2g, $2355
contact : Send enquiry to: info@acesobio.com,or by fax to: 1-845-673-1239.
CAS : 918505-84-7
Molecular Weight : 413.83
Formula : C₁₇H₁₄ClF₂N₃O₃S
Storage : at -20°C
Additional information : We offer significant discount for larger quantity order
 Enlarge Image                   Back
←[Previous Product]             


Details:
PLX 4720, developed by Plexxikon, Inc., is a 7-azaindole derivative that inhibits B-Raf (V600E) with an IC50 of 13 nM, defines a class of kinase inhibitor with marked selectivity in both biochemical and cellular assays. PlX 4720 preferentially inhibits the active B-Raf (V600E) kinase compared with a broad spectrum of other kinases, and potent cytotoxic effects are also exclusive to cells bearing the V600E allele. [1][2]
 
Reference:
[1] Nature, 2010, 464(7287), 427-430.
[2] Nature, 2010, 464(7287), 431-435.
 
                                          
Chemical Information
Molecular Weight (WM):
413.04
Formula:
C17H14ClF2N3O3S
CAS No:
918505-84-7
Purity:
≥ 98%
Synonyms:
PLX-4720
 
DMSO ≥ 83 mg/mL
Solubility: (R.T.: 25℃):
Water < 1 mg/mL
 
Ethanol < 1 mg/mL
 
2 years     -20℃        Powder
Stability:
2 weeks     -4℃        in DMSO
 
2 months    -80℃       in DMSO
 
Quality control data:
Quality control by 1H-NMR, 13C-NMR, HPLC and LCMS.
Product will be shipped with supporting analytical data.
 
PLEASE KEEP THE PRODUCT UNDER -20℃ FOR LONG-TERM STORAGE.
 
NOT FOR HUMAN OR VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.
 

Related Products :
Dabrafenib (GSK 2118436)
Dabrafenib (GSK 2118436)
Price: 200mg, $459;500mg, $850; 1g, $1195; 2g, $1795
PLX 4032 (RG 7204, Zelboraf, RO 5185426)
PLX 4032 (RG 7204, Zelboraf, RO 5185426)
Price: 1g, $650;2g, $1050; 5g $1650
NVP-BHG712
NVP-BHG712
Price: 200mg, $659;500mg, $1050; 1g $1595; 2g, $2355
SB 590885
SB 590885
Price: 200mg, $1350;500mg, $1950; 1g $2650; 2g, $3750
GDC 0879
GDC 0879
Price: 200mg, $1350;500mg, $1950; 1g $2650; 2g, $3750
LGX-818
LGX-818
Price: 200mg, $1250;500mg, $2090; 1g, $2995; 2g, $4395
Sorafenib (Nexavar)
Sorafenib (Nexavar)
Price: 2g, $650;5g, $1050; 10g $1650
AZ 628
AZ 628
Price: 200mg, $850;500mg, $1650; 1g $2250; 2g, $3450