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Product name : MK 8245
Item : cc136
Price : 10mg, $295; 50mg, $795; 100mg, $1295; 200mg, $1995
contact : Send inquiry to: info@acesobio.com,or by fax to: 1-845-673-1239.
Additional Information : We offer significant discount for bulky quantity order
CAS : 
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Details:
MK-8245 is an inhibitor of stearoyl-CoA desaturase (SCD) which targets the liver with IC50 values of 1 nM for human SCD1 and 3 nM for both rat SCD1 and mouse SCD1. When SCD inhibition has been measured by desaturation index in tissues of rodents treated with MK8245, the desaturation index was significantly reduced in liver but not in other tissues such as skin, eye and adipose tissue.    [1][2]
 
Reference:
[1] J Med. Chem. 2011, 54, 5082-5096.
[2] J Lipid Res. 2011, 52, 1494-1499.
 
 
Chemical Information
Molecular Weight (WM):
467.25
Formula:
C17H16BrFN6O4
CAS No:
1030612-87-3
Purity:
≥ 98%
Synonyms:
MK 8245
 
DMSO ≥ 93 mg/mL
Solubility (25℃)
Water < 1 mg/mL
 
Ethanol < 1 mg/mL
 
2 years     -20℃        Powder
Stability:
2 weeks     -4℃        in DMSO
 
2 months    -80℃       in DMSO
 
Quality control data:
Quality control by 1H-NMR, 13C-NMR, HPLC and LCMS.
Product will be shipped with supporting analytical data.
 
PLEASE KEEP THE PRODUCT UNDER -20℃ FOR LONG-TERM STORAGE.
 
NOT FOR HUMAN OR VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.

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