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Product name : AT 7519
Item : cc301
Price : 10mg, $195; 50mg, $595; 100mg, $995; 200mg, $1695
contact : Send inquiry to: info@acesobio.com,or by fax to: 1-845-673-1239.
Additional Information : We offer significant discount for bulky quantity order
CAS : 
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Details:
AT-7519 is a novel small molecule. It is a multi-cyclin-dependent kinase inhibitor with IC50 values of 210 nM, 47 nM, 360 nM, 100 nM, 13 nM and 170 nM for CDK1/cyclin B, CDK2/Cyclin A, CDK3/Cyclin E, CDk4/Cyclin D1, CDk5/p35 and CDK6/Cyclin D3, respectively. AT7519 selectively binds to and inhibits cyclin dependent kinases (CDKs), which may result in cell cycle arrest, induction of apoptosis, and inhibition of tumor cell proliferation. CDKs are serine/theronine kinases involved in regulation of the cell cycle and may be overexpressed in some types of cancer cells.   [1][2]
 
Reference:
[1] Mol. Cancer Ther. 2009, 8, 324-332.
[2] Oncogene 2010, 29, 2325-2336.
 
 
Chemical Information
Molecular Weight (WM):
382.24
Formula:
C16H17Cl2N5O2
CAS No:
844442-38-2, 902135-91-5 (HCl), 902135-89-1 (methanesulfonate
Purity:
≥ 98%
Synonyms:
AT 7519
 
DMSO ≥ 25 mg/mL
Solubility (25℃)
Water < 1 mg/mL
 
Ethanol < 1 mg/mL
 
2 years     -20℃        Powder
Stability:
2 weeks     -4℃        in DMSO
 
2 months    -80℃       in DMSO
 
Quality control data:
Quality control by 1H-NMR, 13C-NMR, HPLC and LCMS.
Product will be shipped with supporting analytical data.
 
PLEASE KEEP THE PRODUCT UNDER -20℃ FOR LONG-TERM STORAGE.
 
NOT FOR HUMAN OR VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.
 
 

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