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Product name : PD 318088
Item : cc-457
Price : 10mg, $275; 50mg, $875; 100mg, $1495; 200mg, $2395
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Additional Information : We offer significant discount for larger quantity order
CAS : 
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Details:
PD 318088 is a non-ATP competitive allosteric MEK1/2 inhibitor. It is a small-molecule inhibitor bound within the allosteric site. The binding modes of two kinase inhibitors are shown in relation to the binding site of ATP in the kinase active site. The MEK1 inhibitor PD318088 binds simultaneously with ATP in a region of the kinase active site that is adjacent to the ATP-binding site. Birb796 binding to p38  extends into the ATP site, but also accesses this back pocket, partly overlapping the region where PD318088 binds in MEK1. [1][2]
 
Reference:
[1] Nature Structural & Molecular Biology. 2004, 11, 1192-1197.
[2] Nature 2006, 441, 457-462.
                                          
Chemical Information
Molecular Weight (WM):
561.09
Formula:
C16H13BrF3IN2O4
CAS No:
391210-00-7
Purity:
≥ 98%
Synonyms:
PD-318088
 
DMSO ≥ 112 mg/mL
Solubility: (R.T.: 25℃):
Water < 1 mg/mL
 
Ethanol ≥ 14 mg/mL
 
2 years     -20℃        Powder
Stability:
2 weeks     -4℃        in DMSO
 
2 months    -80℃       in DMSO
 
Quality control data:
Quality control by 1H-NMR, 13C-NMR, HPLC and LCMS.
Product will be shipped with supporting analytical data.
 
PLEASE KEEP THE PRODUCT UNDER -20℃ FOR LONG-TERM STORAGE.
 
NOT FOR HUMAN OR VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.
 

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