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Product name : AZD 8330
Item : cc-458
Price : 200mg, $750;500mg, $1250; 1g $1850; 2g, $3050
contact : Send enquiry to: info@acesobio.com,or by fax to: 1-845-673-1239.
CAS : 869357-68-6
Molecular Weight : 461.23
Formula : C₁₆H₁₇FIN₃O₄
Storage : at -20°C
Additional information : We offer significant discount for larger quantity order
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Details:
AZD 8330 is an orally active, selective MEK inhibitor with IC50 of 7 nM. MEK inhibitor AZD8330 specifically inhibits mitogen-activated protein kinase kinase 1 (MEK or MAP/ERK kinase1), resulting in inhibition of growth factor-mediated cell signaling and tumor cell proliferation. MEK is a key component of the RAS/RAF/MEK/ERK signaling pathway that regulates cell growth; constitutive activation of this pathway has been implicated in many cancers. [1]
 
Reference:
[1] Journal of Hematology & Oncology, 2010, 3,8
                                          
Chemical Information
Molecular Weight (WM):
461.23
Formula:
C16H17FIN3O4
CAS No:
869357-68-6
Purity:
≥ 98%
Synonyms:
ARRY 424704, ARRY 704, AZD-8330
 
DMSO ≥ 92 mg/mL
Solubility: (R.T.: 25℃):
Water < 1 mg/mL
 
Ethanol ≥ 92 mg/mL
 
2 years     -20℃        Powder
Stability:
2 weeks     -4℃        in DMSO
 
2 months    -80℃       in DMSO
 
Quality control data:
Quality control by 1H-NMR, 13C-NMR, HPLC and LCMS.
Product will be shipped with supporting analytical data.
 
PLEASE KEEP THE PRODUCT UNDER -20℃ FOR LONG-TERM STORAGE.
 
NOT FOR HUMAN OR VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.
 

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