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Product name : PCI 32765
Item : cc214
Price : 10mg, $275; 50mg, $895; 100mg, $1345; 200mg, $2195
contact : Send inquiry to: info@acesobio.com,or by fax to: 1-845-673-1239.
Additional Information : We offer significant discount for bulky quantity order
CAS : 
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Details:
PCI-32765 (Ibrutinib) is a potent and highly selective Bruton's tyrosine kinase (Btk) inhibitor with IC50 of 0.5 nM. PCI32765 binds to and inhibits BTK activity, preventing B-cell activation and B-cell-mediated signaling and inhibiting the growth of malignant B cells that overexpress BTK. BTK, a member of the src-related BTK/Tec family of cytoplasmic tyrosine kinases, is required for B cell receptor (BCR) signaling, plays a key role in B-cell maturation, and is overexpressed in a number of B-cell malignancies.  [1][2]
 
Reference:
[1] Proc. Natl. Acad. Sci. USA 2010, 107, 13075-13080.
[2] Blood 2011, 117, 6287-6296.
 
 
Chemical Information
Molecular Weight (WM):
440.50
Formula:
C25H24N6O2
CAS No:
936563-96-1
Purity:
≥ 98%
Synonyms:
PCI 32765
 
DMSO ≥ 88 mg/mL
Solubility (25℃)
Water < 1 mg/mL
 
Ethanol ≥ 2 mg/mL
 
2 years     -20℃        Powder
Stability:
2 weeks     -4℃        in DMSO
 
2 months    -80℃       in DMSO
 
Quality control data:
Quality control by 1H-NMR, 13C-NMR, HPLC and LCMS.
Product will be shipped with supporting analytical data.
 
PLEASE KEEP THE PRODUCT UNDER -20℃ FOR LONG-TERM STORAGE.
 
NOT FOR HUMAN OR VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.

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