Apoptosis
Btk
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Product name : AEE 788
Item : cc434
Price : 200mg, $950;500mg, $1595; 1g $2390; 2g, $3590
contact : Send inquiry to: info@acesobio.com,or by fax to: 1-845-673-1239.
CAS : 497839-62-0
Molecular Weight : 440.58
Formula : C₂₇H₃₂N₆
Storage : at -20°C
Additional information : We offer significant discount for bulky quantity order
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AEE788 (NVP-AEE788) is a novel multitargeted human epidermal receptor (HER) 1/2 and vascular endothelial growth factor receptor (VEGFR) 1/2 receptor family tyrosine kinases inhibitor with IC50 of 2, 6, 77, 59 nM for EGFR, ErbB2, KDR, and Flt-1. In cells, growth factor-induced EGFR and ErbB2 phosphorylation was also efficiently inhibited with IC50s of 11 and 220 nM, respectively. AEE-788 efficiently inhibited growth factor-induced EGFR and ErbB2 phosphorylation in tumors for >72 h, a phenomenon correlating with the antitumor efficacy of intermittent treatment schedules. AEE 788 also inhibits VEGF-induced angiogenesis in a murine implant model. It has potential as an anticancer agent targeting deregulated tumor cell proliferation as well as angiogenic parameters. [1][2]
Reference:
[1] Cancer Res. 2004, 64, 4931-4941.
[2] Cancer Res. 2005, 65, 3716-3725.
Chemical Information
PLEASE KEEP THE PRODUCT UNDER -20℃ FOR LONG-TERM STORAGE.
NOT FOR HUMAN OR VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.
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