Product name : AS 703026 (AS703026)
Item : cc-460
Price : 200mg, $650;500mg, $950; 1g $1650; 2g, $2850
contact : Send inquiry to: info@acesobio.com,or by fax to: 1-845-673-1239.
CAS : 1236699-92-5
Molecular Weight : 431.2
Formula : C₁₅H₁₅FIN₃O₃
Storage : at -20°C
Additional information : We offer significant discount for larger quantity order
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MEK inhibitor AS703026 selectively binds to and inhibits the activity of MEK1/2 with IC50 value ranging from 2 nM to 20 μM, preventing the activation of MEK1/2-dependent effector proteins and transcription factors, which may result in the inhibition of growth factor-mediated cell signaling and tumor cell proliferation. MEK1/2 (MAP2K1/K2) are dual-specificity threonine/tyrosine kinases that play key roles in the activation of the RAS/RAF/MEK/ERK pathway and are often upregulated in a variety of tumor cell types. [1][2]
Reference:
[1] J Haematol. 2010, 149, 537-549.
[2] Cancer Res. 2011, 71, 445-453.
Chemical Information
PLEASE KEEP THE PRODUCT UNDER -20℃ FOR LONG-TERM STORAGE.
NOT FOR HUMAN OR VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.
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