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Products > MAPK > MEK > AS 703026 (AS703026)
Product name : AS 703026 (AS703026)
Item : cc-460
Price : 10mg, $125; 50mg, $395; 100mg, $595; 200mg, $995
contact : Send inquiry to: info@acesobio.com,or by fax to: 1-845-673-1239.
Additional Information : We offer significant discount for larger quantity order
CAS : 
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Details:
MEK inhibitor AS703026 selectively binds to and inhibits the activity of MEK1/2 with IC50 value ranging from 2 nM to 20 μM, preventing the activation of MEK1/2-dependent effector proteins and transcription factors, which may result in the inhibition of growth factor-mediated cell signaling and tumor cell proliferation. MEK1/2 (MAP2K1/K2) are dual-specificity threonine/tyrosine kinases that play key roles in the activation of the RAS/RAF/MEK/ERK pathway and are often upregulated in a variety of tumor cell types. [1][2]
 
Reference:
[1] J Haematol. 2010, 149, 537-549.
[2] Cancer Res. 2011, 71, 445-453.
                                         
Chemical Information
Molecular Weight (WM):
431.20
Formula:
C15H15FIN3O3
CAS No:
1236699-92-5, 1236361-78-6 (HCl)
Purity:
≥ 98%
Synonyms:
AS-703026
 
DMSO ≥ 86g/mL
Solubility: (R.T.: 25℃):
Water < 1 mg/mL
 
Ethanol ≥ 3 mg/mL
 
2 years     -20℃        Powder
Stability:
2 weeks     -4℃        in DMSO
 
6months    -80℃       in DMSO
 
Quality control data:
Quality control by 1H-NMR, 13C-NMR, HPLC and LCMS.
Product will be shipped with supporting analytical data.
 
PLEASE KEEP THE PRODUCT UNDER -20℃ FOR LONG-TERM STORAGE.
 
NOT FOR HUMAN OR VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.
 
 

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