Favorite  |  Set Home
Products > Aurora/Ksp > KSp > Ispinesib (SB 715992, CK 0238273)
Product name : Ispinesib (SB 715992, CK 0238273)
Item : cc435
Price : 200mg, $950;500mg, $1595; 1g $2390; 2g, $3590
contact : Send inquiry to: info@acesobio.com,or by fax to: 1-845-673-1239.
CAS : 336113-53-2
Molecular Weight : 517.06
Formula : C₃₀H₃₃ClN₄O₂
Storage : at -20°C
Additional information : We offer significant discount for bulky quantity order
 Enlarge Image                   Back
←[Previous Product]              [Next Product]→


Details:
Ispinesib (SB-715992, CK0238273) is an allosteric, potent, specific, and reversible inhibitor of KSP (HsEg5) with Ki of 1.7 nM.  Ispinesib selectively inhibits the mitotic motor protein, kinesin spindle protein (KSP), resulting in inhibition of mitotic spindle assembly, induction of cell cycle arrest during the mitotic phase, and cell death in tumor cells that are actively dividing. Because KSP is not involved in nonmitotic processes, such as neuronal transport, ispinesib may be less likely to cause the peripheral neuropathy often associated with the tubulin-targeting agents.   [1][2]
 
Reference:
[1] Biochemistry 2008, 47, 3576-3585.
[2] Clin. Cancer Res. 2010, 16, 566-576.
 
 
Chemical Information
Molecular Weight (WM):
517.06
Formula:
C30H33ClN4O2
CAS No:
336113-53-2, 514820-03-2 (methanesulfonate), 514820-04-3 (HCl)
Purity:
≥ 98%
Synonyms:
SB715992, CK-0238273
 
DMSO ≥ 103 mg/mL
Solubility (25℃)
Water < 1 mg/mL
 
Ethanol ≥ 103 mg/mL
 
2 years     -20℃        Powder
Stability:
2 weeks     -4℃        in DMSO
 
2 months    -80℃       in DMSO
 
Quality control data:
Quality control by 1H-NMR, 13C-NMR, HPLC and LCMS.
Product will be shipped with supporting analytical data.
 
PLEASE KEEP THE PRODUCT UNDER -20℃ FOR LONG-TERM STORAGE.
 
NOT FOR HUMAN OR VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.

Related Products :
AZ 3146
AZ 3146
Price: 200mg, $950;500mg, $1595; 1g $2390; 2g, $3590
ARRY 520
ARRY 520
Price: 200mg, $1750;500mg, $2690; 1g $3590; 2g, $5190
AZD 4877
AZD 4877
Price: 200mg, $1750;500mg, $2690; 1g $3590;
MPS-1-IN-1
MPS-1-IN-1
Price: 200mg, $1750;500mg, $2690; 1g $3590; 2g, $5190
SB 743921
SB 743921
Price: 200mg, $750;500mg, $1350; 1g $1950; 2g, $3150