Product name : Ispinesib (SB 715992, CK 0238273)
Item : cc435
Price : 200mg, $950;500mg, $1595; 1g $2390; 2g, $3590
contact : Send inquiry to: info@acesobio.com,or by fax to: 1-845-673-1239.
CAS : 336113-53-2
Molecular Weight : 517.06
Formula : C₃₀H₃₃ClN₄O₂
Storage : at -20°C
Additional information : We offer significant discount for bulky quantity order
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Ispinesib (SB-715992, CK0238273) is an allosteric, potent, specific, and reversible inhibitor of KSP (HsEg5) with Ki of 1.7 nM. Ispinesib selectively inhibits the mitotic motor protein, kinesin spindle protein (KSP), resulting in inhibition of mitotic spindle assembly, induction of cell cycle arrest during the mitotic phase, and cell death in tumor cells that are actively dividing. Because KSP is not involved in nonmitotic processes, such as neuronal transport, ispinesib may be less likely to cause the peripheral neuropathy often associated with the tubulin-targeting agents. [1][2]
Reference:
[1] Biochemistry 2008, 47, 3576-3585.
[2] Clin. Cancer Res. 2010, 16, 566-576.
Chemical Information
PLEASE KEEP THE PRODUCT UNDER -20℃ FOR LONG-TERM STORAGE.
NOT FOR HUMAN OR VETERINARY DIAGNOSTIC OR THERAPEUTIC USE. |
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