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Products > MAPK > MEK > CI 1040 (PD 184352)
Product name : CI 1040 (PD 184352)
Item : cc-384
Price : 10mg, $110; 25mg, $250; 100mg, $595; 200mg, $855
contact : Send inquiry to: info@acesobio.com,or by fax to: 1-845-673-1239.
Additional Information : We offer significant discount for larger quantity order
CAS : 
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Details:
PD184352 (CI-1040) is a highly selective non-competitive inhibitor of MEK (MKK1; MAPK kinase) and the closely related MKK2 with a Ki of 300 nM in vitro. It has anti-cancer activity, suppresses the ERK pathway, and has been used along with other classes of inhibitors to establish embryonic stem cell lines. [1][2]
 
Reference:
[1] Nature. Medicine 1999, 5, 810-816.
[2] Nature. 2006, 439, 358-362.
                                         
Chemical Information
Molecular Weight (WM):
478.67
Formula:
C17H14ClF2IN2O2
CAS No:
212631-79-3
Purity:
≥ 98%
Synonyms:
PD 184352, PD-184352, CI-1040
 
DMSO ≥ 96g/mL
Solubility: (R.T.: 25℃):
Water < 1 mg/mL
 
Ethanol ≥ 16 mg/mL
 
2 years     -20℃        Powder
Stability:
2 weeks     -4℃        in DMSO
 
6months    -80℃       in DMSO
 
Quality control data:
Quality control by 1H-NMR, 13C-NMR, HPLC and LCMS.
Product will be shipped with supporting analytical data.
 
PLEASE KEEP THE PRODUCT UNDER -20℃ FOR LONG-TERM STORAGE.
 
NOT FOR HUMAN OR VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.
 
 

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