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Product name : MLN-9708 (Ixazomib)
Item : cc436
Price : 200mg, $459;500mg, $850; 1g $1195; 2g, $1795
contact : Send inquiry to: info@acesobio.com,or by fax to: 1-845-673-1239.
CAS : 1239908-20-3
Molecular Weight : 517.12
Formula : C₂₀H₂₃BCl₂N₂O₉
Storage : at -20°C
Additional information : We offer significant discount for bulky quantity order
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Details:
MLN-9708 (Ixazomib) is a selective, orally bioavailable, second-generation proteasome inhibitor of chymotrypsin-like proteolytic (β5) site of the 20S proteasome with IC50 and Ki of 3.4 nM and 0.93 nM. MLN9708 inhibits the activity of the proteasome, blocking the targeted proteolysis normally performed by the proteasome, which results in an accumulation of unwanted or misfolded proteins; disruption of various cell signaling pathways may follow, resulting in the induction of apoptosis. Compared to first generation PIs, second generation PIs may have an improved pharmacokinetic profile with increased potency and less toxicity. Proteasomes are large protease complexes that degrade unneeded or damaged proteins that have been ubiquinated.  [1][2]
 
Reference:
[1] Cancer Res. 2010, 70, 1970-1980.
[2] Clin. Cancer Res. 2011, 17, 5311-5321.
 
 
Chemical Information
Molecular Weight (WM):
517.12
Formula:
C20H23BCl2N2O9
CAS No:
1201902-80-8
Purity:
≥ 98%
Synonyms:
MLN 9708
 
DMSO ≥ 103 mg/mL
Solubility (25℃)
Water < 1 mg/mL
 
Ethanol < 5 mg/mL
 
2 years     -20℃        Powder
Stability:
2 weeks     -4℃        in DMSO
 
2 months    -80℃       in DMSO
 
Quality control data:
Quality control by 1H-NMR, 13C-NMR, HPLC and LCMS.
Product will be shipped with supporting analytical data.
 
PLEASE KEEP THE PRODUCT UNDER -20℃ FOR LONG-TERM STORAGE.
 
NOT FOR HUMAN OR VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.

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