Product name : MLN-9708 (Ixazomib)
Item : cc436
Price : 200mg, $459;500mg, $850; 1g $1195; 2g, $1795
contact : Send inquiry to: info@acesobio.com,or by fax to: 1-845-673-1239.
CAS : 1239908-20-3
Molecular Weight : 517.12
Formula : C₂₀H₂₃BCl₂N₂O₉
Storage : at -20°C
Additional information : We offer significant discount for bulky quantity order
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MLN-9708 (Ixazomib) is a selective, orally bioavailable, second-generation proteasome inhibitor of chymotrypsin-like proteolytic (β5) site of the 20S proteasome with IC50 and Ki of 3.4 nM and 0.93 nM. MLN9708 inhibits the activity of the proteasome, blocking the targeted proteolysis normally performed by the proteasome, which results in an accumulation of unwanted or misfolded proteins; disruption of various cell signaling pathways may follow, resulting in the induction of apoptosis. Compared to first generation PIs, second generation PIs may have an improved pharmacokinetic profile with increased potency and less toxicity. Proteasomes are large protease complexes that degrade unneeded or damaged proteins that have been ubiquinated. [1][2]
Reference:
[1] Cancer Res. 2010, 70, 1970-1980.
[2] Clin. Cancer Res. 2011, 17, 5311-5321.
Chemical Information
PLEASE KEEP THE PRODUCT UNDER -20℃ FOR LONG-TERM STORAGE.
NOT FOR HUMAN OR VETERINARY DIAGNOSTIC OR THERAPEUTIC USE. |
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