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Product name : LY2109761
Item : cc120
Price : 10mg, $295; 50mg, $795; 100mg, $1395; 200mg, $2395
contact : Send inquiry to: info@acesobio.com,or by fax to: 1-845-673-1239.
Additional Information : We offer significant discount for bulky quantity order
CAS : 
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Details:
LY2109761 is a novel selective TGFβ receptor type I and type II (TβRI/II) dual inhibitor with Ki of 38 nM and 300 nM, respectively. Blocking TβRI/II kinase activity with LY-2109761 (5 μM) completely suppresses both the basal and TGF-β1-stimulated migration and invasion of L3.6pl/GLT cells, significantly enhances the detachment-induced apoptosis by 26% at 8 hours treatment, and completely suppresses TGF-β–induced Smad2 phosphorylation. LY 2109761 treatment at 1 nM is sufficient to significantly block the migration and invasion but not adhesion of hepatocellular carcinoma cells by increasing E-cadherin expression.  [1][2]
 
Reference:
[1] Mol. Cancer Ther. 2008, 7, 829-840.
[2] Hepatology 2008, 47, 1557-1566.
 
 
Chemical Information
Molecular Weight (WM):
441.52
Formula:
C26H27N5O2
CAS No:
700874-71-1
Purity:
≥ 98%
Synonyms:
 
 
DMSO ≥ 3 mg/mL
Solubility (25℃)
Water < 1 mg/mL
 
Ethanol ≥ 15 mg/mL
 
2 years     -20℃        Powder
Stability:
2 weeks     -4℃        in DMSO
 
2 months    -80℃       in DMSO
 
Quality control data:
Quality control by 1H-NMR, 13C-NMR, HPLC and LCMS.
Product will be shipped with supporting analytical data.
 
PLEASE KEEP THE PRODUCT UNDER -20℃ FOR LONG-TERM STORAGE.
 
NOT FOR HUMAN OR VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.

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