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Product name : SGI 1776
Item : cc574
Price : 10mg, $195; 50mg, $595; 100mg, $895; 200mg, $1355
contact : Send inquiry to: info@acesobio.com,or by fax to: 1-845-673-1239.
Additional Information : We offer significant discount for bulky quantity order
CAS : 
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Details:
SGI-1776 is a novel ATP competitive inhibitor to Pim1, Pim2 and Pim3 with IC50 of 7 nM, 363 nM and 69 nM, respectively. Pim kinase inhibitor SGI1776 binds to and inhibits the activities of Pim-1, -2 and -3, serine-threonine kinases, which may result in the interruption of the G1/S phase cell cycle transition, the expression of pro-apoptotic Bcl2 proteins and tumor cell apoptosis. PIM kinases play key roles in cell cycle progression and apoptosis inhibition and may be overexpressed in various malignancies.  [1][2]
 
Reference:
[1] Blood 2011, 118, 693-702.
[2] Blood 2009, 114, 4150-4157.
 
 
Chemical Information
Molecular Weight (WM):
405.42
Formula:
C20H22F3N5O
CAS No:
1025065-69-3, 1173928-26-1 (2H2SO4)
Purity:
≥ 98%
Synonyms:
SGI 1776
 
DMSO ≥ 81 mg/mL
Solubility (25℃)
Water < 1 mg/mL
 
Ethanol ≥ 81 mg/mL
 
2 years     -20℃        Powder
Stability:
2 weeks     -4℃        in DMSO
 
2 months    -80℃       in DMSO
 
Quality control data:
Quality control by 1H-NMR, 13C-NMR, HPLC and LCMS.
Product will be shipped with supporting analytical data.
 
PLEASE KEEP THE PRODUCT UNDER -20℃ FOR LONG-TERM STORAGE.
 
NOT FOR HUMAN OR VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.
 

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