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Product name : GDC 0973 (XL 518)
Item : cc-456
Price : 10mg, $595; 25mg, $895; 100mg, $2495; 200mg, $3495
contact : Send inquiry to: info@acesobio.com,or by fax to: 1-845-673-1239.
Additional Information : We offer significant discount for larger quantity order
CAS : 
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Details:
GDC 0973 is an orally bioavailable small-molecule inhibitor of mitogen-activated protein kinase kinase 1 (MAP2K1 or MEK1), with potential antineoplastic activity. MEK inhibitor GDC-0973 specifically binds to and inhibits the catalytic activity of MEK1, resulting in inhibition of extracellular signal-related kinase 2 (ERK2) phosphorylation and activation and decreased tumor cell proliferation. Preclinical studies have demonstrated that this agent is effective in inhibiting the growth of tumor cells bearing a B-RAF mutation, which has been found to be associated with many tumor types. A threonine-tyrosine kinase and a key component of the RAS/RAF/MEK/ERK signaling pathway that is frequently activated in human tumors, MEK1 is required for the transmission of growth-promoting signals from numerous receptor tyrosine kinases.  [1]
 
Reference:
[1] Cancer Res. 2011, 72, 210-219.
                                        
Chemical Information
Molecular Weight (WM):
531.31
Formula:
C21H21F3IN3O2
CAS No:
934660-93-2
Purity:
≥ 98%
Synonyms:
GDC-0973, XL 518, XL-518,
 
DMSO N/A
Solubility: (R.T.: 25℃):
Water N/A
 
Ethanol N/A
 
2 years     -20℃        Powder
Stability:
2 weeks     -4℃        in DMSO
 
6months    -80℃       in DMSO
 
Quality control data:
Quality control by 1H-NMR, 13C-NMR, HPLC and LCMS.
Product will be shipped with supporting analytical data.
 
PLEASE KEEP THE PRODUCT UNDER -20℃ FOR LONG-TERM STORAGE.
 
NOT FOR HUMAN OR VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.

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