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Product name : Enzastaurin (LY 317615)
Item : cc575
Price : 10mg, $125; 50mg, $325; 100mg, $595; 200mg, $925
contact : Send inquiry to: info@acesobio.com,or by fax to: 1-845-673-1239.
Additional Information : We offer significant discount for bulky quantity order
CAS : 
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Details:
Enzastaurin (LY-317615) is a potent PKC beta inhibitor for PKCβ, PKCα, PKCγ and PKCε with IC50 of 6 nM, 39 nM, 83 nM and 110 nM, respectively. Binding to the ATP-binding site, enzastaurin (LY317615) selectively inhibits protein kinase C beta, an enzyme involved in the induction of vascular endothelial growth factor (VEGF)-stimulated neo-angiogenesis. This agent may decrease tumor blood supply and so tumor burden.  [1][2]
 
Reference:
[1] Cancer Res. 2005, 65, 7462-7569.
[2] Blood 2007, 109, 1669-1677.
 

Chemical Information
Molecular Weight (WM):
515.61
Formula:
C32H29N5O2
CAS No:
170364-57-5, 365253-37-8 (2HCl)
Purity:
≥ 98%
Synonyms:
LY 317615
 
DMSO ≥ 50 mg/mL
Solubility (25℃)
Water < 1 mg/mL
 
Ethanol < 1 mg/mL
 
2 years     -20℃        Powder
Stability:
2 weeks     -4℃        in DMSO
 
2 months    -80℃       in DMSO
 
Quality control data:
Quality control by 1H-NMR, 13C-NMR, HPLC and LCMS.
Product will be shipped with supporting analytical data.
 
PLEASE KEEP THE PRODUCT UNDER -20℃ FOR LONG-TERM STORAGE.
 
NOT FOR HUMAN OR VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.

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