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Products > Cell Cycle > CDK > Flavopiridol (HMR 1275, L 868275)
Product name : Flavopiridol (HMR 1275, L 868275)
Item : cc206
Price : 10mg, $75, 50mg, $275; 100mg, $495; 200mg, $795
contact : Send inquiry to: info@acesobio.com,or by fax to: 1-845-673-1239.
Additional Information : We offer significant discount for bulky quantity order
CAS : 
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Details:
Flavopiridol (Alvocidib, HMR-1275, L-868275) is a pan-CDK inhibitor targeting CDK1, CDK2, CDK4, CDK5, CDK6, and CDK9 with IC50 of 30 nM, 170 nM, 100 nM, 170 nM, 80 nM and 20 nM, respectively. It inhibits the phosphorylation of cyclin-dependent kinases (CDKs) and suppresses expression of cyclin D1 and D3, interrupting the central role of CDKs in the regulation of the cell cycle and consequently promoting apoptosis. This action has been exploited in studies investigating the suppression of oncogenic proliferation, synovial hyperplasia, and joint destruction related to rheumatoid arthritis.  [1][2]
 
Reference:
[1] Proc. Natl. Acad. Sci. USA 1996, 93, 2735-2740.
[2] J Clin. Invest. 1998, 102, 1674-1681.
 
 
Chemical Information
Molecular Weight (WM):
401.84
Formula:
C21H20ClNO5
CAS No:
146426-40-6, 131740-09-5(HCl), 358739-41-0 (TFA)
Purity:
≥ 98%
Synonyms:
HMR1275, L868275
 
DMSO ≥ 15 mg/mL
Solubility (25℃)
Water < 1 mg/mL
 
Ethanol < 8 mg/mL
 
2 years     -20℃        Powder
Stability:
2 weeks     -4℃        in DMSO
 
2 months    -80℃       in DMSO
 
Quality control data:
Quality control by 1H-NMR, 13C-NMR, HPLC and LCMS.
Product will be shipped with supporting analytical data.
 
PLEASE KEEP THE PRODUCT UNDER -20℃ FOR LONG-TERM STORAGE.
 
NOT FOR HUMAN OR VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.
 

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