Favorite  |  Set Home
Products > Cell Cycle > CDK > R 547
Product name : R 547
Item : cc270
Price : 200mg, $1250;500mg, $2090; 1g $2995; 2g, $4395
contact : Send inquiry to: info@acesobio.com,or by fax to: 1-845-673-1239.
CAS : 741713-40-6
Molecular Weight : 441.45
Formula : C₁₈H₂₁F₂N₅O₄S
Storage : at -20°C
Additional information : We offer significant discount for bulky quantity order
 Enlarge Image                   Back
←[Previous Product]              [Next Product]→


Details:
R547 is a novel, selective inhibitor of cell cycle and transcriptional cyclin dependent kinases (CDKs) (Ki = 1, 3, and 1 nM for CDK1, CDK2, and CDK4, respectively) with excellent in vitro cellular potency that inhibits the growth of various human tumor cell lines. R-547 selectively binds to and inhibits CDKs, especially CDK1/cyclin B, CDK2/cyclin E, and CDK4/cyclin D1. The inhibition of CDKs results in cell cycle arrest, inhibition of tumor cell proliferation, and induction of apoptosis. Through CDK inhibition, this agent also reduces phosphorylation of the retinoblastoma (Rb) protein, thus preventing activation of transcription factor E2F and so further suppressing tumor cell proliferation. CDKs are ATP-dependent serine/threonine kinases that are important regulators of cell cycle progression and are frequently overexpressed in tumor cells. [1][2]
 
Reference:
[1] Mol. Cancer Ther. 2006, 5, 2644-2658.
[2] J Med. Chem. 2006, 49, 6549-6560.
 
 
Chemical Information
Molecular Weight (WM):
441.45
Formula:
C18H21F2N5O4S
CAS No:
741713-40-6, 869369-26-6 (methanesulfonate)
Purity:
≥ 98%
Synonyms:
CDKI R547, R 547
 
2 years     -20℃        Powder
Stability:
2 weeks     -4℃        in DMSO
 
2 months    -80℃       in DMSO
 
Quality control data:
Quality control by 1H-NMR, 13C-NMR, HPLC and LCMS.
Product will be shipped with supporting analytical data.
 
PLEASE KEEP THE PRODUCT UNDER -20℃ FOR LONG-TERM STORAGE.
 
NOT FOR HUMAN OR VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.
 

Related Products :
AT 7519
AT 7519
Price: 200mg, $459;500mg, $850; 1g $1195; 2g, $1795
PHA 793887
PHA 793887
Price: 200mg, $1250;500mg, $2090; 1g $2995; 2g, $4395
CGP 60474
CGP 60474
Price: 200mg, $950;500mg, $1595; 1g $2390; 2g, $3590
MSC2530818
MSC2530818
Price: 200mg, $1250;500mg, $2090; 1g, $2995; 2g, $4395
PHA 767491
PHA 767491
Price: 200mg, $659;500mg, $1050; 1g $1595; 2g, $2355
BS 181
BS 181
Price: 200mg, $659;500mg, $1050; 1g $1595; 2g, $2355
Flavopiridol (HMR 1275, L 868275)
Flavopiridol (HMR 1275, L 868275)
Price: 200mg, $659;500mg, $1050; 1g $1595; 2g, $2355
JNJ 7706621
JNJ 7706621
Price: 200mg, $850;500mg, $1650; 1g $2250; 2g, $3450