Favorite  |  Set Home
Products > Cell Cycle > CDK > PHA 848125
Product name : PHA 848125
Item : cc78
Price : 10mg, $295; 50mg, $895; 100mg, $1295; 200mg, $2195
contact : Send inquiry to: info@acesobio.com,or by fax to: 1-845-673-1239.
Additional Information : We offer significant discount for bulky quantity order
CAS : 
 Enlarge Image                   Back
←[Previous Product]              [Next Product]→


Details:
PHA-848125 is a potent, ATP-competitive cyclin A/CDK2 inhibitor with an IC50 of 45 nM. PHA848125 potently inhibits cyclin-dependent kinase 2 (CDK2) and exhibits activity against other CDKs including CDK1 and CDK4, in addition to TRKA. Inhibition of these kinases may result in cell cycle arrest and apoptosis of tumor cells that express these kinases. CDKs are serine/threonine kinases involved in regulation of the cell cycle and may be overexpressed in some cancer cell types. The neurotrophin receptor TRKA is mutated in a variety of cancer cell types. [1][2]
 
Reference:
[1] Mol. Cancer Ther. 2010, 9, 673-681.
[2] J Med. Chem. 2009, 52, 5152-5163.
 
 
Chemical Information
Molecular Weight (WM):
460.57
Formula:
C25H32N8O
CAS No:
802539-81-7, 802540-32-5 (3HCl), 1253645-38-3 (Maleic acid)
Purity:
≥ 98%
Synonyms:
PHA 848125
 
DMSO ≥ 22mg/mL
Solubility (25℃)
Water < 1 mg/mL
 
Ethanol < 1 mg/mL
 
2 years     -20℃        Powder
Stability:
2 weeks     -4℃        in DMSO
 
2 months    -80℃       in DMSO
 
Quality control data:
Quality control by 1H-NMR, 13C-NMR, HPLC and LCMS.
Product will be shipped with supporting analytical data.
 
PLEASE KEEP THE PRODUCT UNDER -20℃ FOR LONG-TERM STORAGE.
 
NOT FOR HUMAN OR VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.

Related Products :
PHA 767491
PHA 767491
Price: 10mg, $75, 50mg, $295; 100mg, $475; 200mg, $795
BS 181
BS 181
Price: 10mg, $245; 50mg, $785; 100mg, $1295; 200mg, $1895
Flavopiridol (HMR 1275, L 868275)
Flavopiridol (HMR 1275, L 868275)
Price: 10mg, $75, 50mg, $275; 100mg, $495; 200mg, $795
JNJ 7706621
JNJ 7706621
Price: 10mg, $325; 50mg, $775; 100mg, $1295; 200mg,$1675
Roscovitine (Seliciclib, CYC 202, R-roscovitine)
Roscovitine (Seliciclib, CYC 202, R-roscovitine)
Price: 10mg, $75, 50mg, $245; 100mg, $445; 200mg, $795
SNS 032 (BMS 387032)
SNS 032 (BMS 387032)
Price: 10mg, $125; 50mg, $475; 100mg, $795; 200mg, $1095
PD 0332991
PD 0332991
Price: 10mg, $125; 50mg, $495; 100mg, $695; 200mg, $1095
AZD 5438
AZD 5438
Price: 10mg, $125; 50mg, $475; 100mg, $795; 200mg, $1095