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Product name : PHA 848125
Item : cc78
Price : 200mg, $1250;500mg, $2090; 1g $2995; 2g, $4395
contact : Send inquiry to: info@acesobio.com,or by fax to: 1-845-673-1239.
CAS : 802539-81-7
Molecular Weight : 460.57
Formula : C₂₅H₃₂N₈O
Storage : at -20°C
Additional information : We offer significant discount for bulky quantity order
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Details:
PHA-848125 is a potent, ATP-competitive cyclin A/CDK2 inhibitor with an IC50 of 45 nM. PHA848125 potently inhibits cyclin-dependent kinase 2 (CDK2) and exhibits activity against other CDKs including CDK1 and CDK4, in addition to TRKA. Inhibition of these kinases may result in cell cycle arrest and apoptosis of tumor cells that express these kinases. CDKs are serine/threonine kinases involved in regulation of the cell cycle and may be overexpressed in some cancer cell types. The neurotrophin receptor TRKA is mutated in a variety of cancer cell types. [1][2]
 
Reference:
[1] Mol. Cancer Ther. 2010, 9, 673-681.
[2] J Med. Chem. 2009, 52, 5152-5163.
 
 
Chemical Information
Molecular Weight (WM):
460.57
Formula:
C25H32N8O
CAS No:
802539-81-7, 802540-32-5 (3HCl), 1253645-38-3 (Maleic acid)
Purity:
≥ 98%
Synonyms:
PHA 848125
 
DMSO ≥ 22mg/mL
Solubility (25℃)
Water < 1 mg/mL
 
Ethanol < 1 mg/mL
 
2 years     -20℃        Powder
Stability:
2 weeks     -4℃        in DMSO
 
2 months    -80℃       in DMSO
 
Quality control data:
Quality control by 1H-NMR, 13C-NMR, HPLC and LCMS.
Product will be shipped with supporting analytical data.
 
PLEASE KEEP THE PRODUCT UNDER -20℃ FOR LONG-TERM STORAGE.
 
NOT FOR HUMAN OR VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.

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