Favorite  |  Set Home
Products > Cell Cycle > CDK > BS 181
Product name : BS 181
Item : cc578
Price : 10mg, $245; 50mg, $785; 100mg, $1295; 200mg, $1895
contact : Send inquiry to: info@acesobio.com,or by fax to: 1-845-673-1239.
Additional Information : We offer significant discount for bulky quantity order
CAS : 
 Enlarge Image                   Back
←[Previous Product]              [Next Product]→


Details:
BS-181 is a highly selective cyclin-dependent kinase (CDK) inhibitor of CDK7 activity with IC50 of 21 nM. CDK7, which also regulates transcription as part of the TFIIH basal transcription factor, is an attractive target for the development of anticancer drugs. In MCF-7 cells, BS181 inhibited the phosphorylation of CDK7 substrates, promoted cell cycle arrest and apoptosis to inhibit the growth of cancer cell lines, and showed antitumor effects in vivo.  [1]
 
Reference:
[1] Cancer Res. 2009, 69, 6208-6215.
 
 
Chemical Information
Molecular Weight (WM):
416.99
Formula:
C22H32N6.HCl
CAS No:
1092443-52-1 (free base)
Purity:
≥ 98%
Synonyms:
BS 181
 
2 years     -20℃        Powder
Stability:
2 weeks     -4℃        in DMSO
 
2 months    -80℃       in DMSO
 
Quality control data:
Quality control by 1H-NMR, 13C-NMR, HPLC and LCMS.
Product will be shipped with supporting analytical data.
 
PLEASE KEEP THE PRODUCT UNDER -20℃ FOR LONG-TERM STORAGE.
 
NOT FOR HUMAN OR VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.

Related Products :
PHA 767491
PHA 767491
Price: 10mg, $75, 50mg, $295; 100mg, $475; 200mg, $795
Roscovitine (Seliciclib, CYC 202, R-roscovitine)
Roscovitine (Seliciclib, CYC 202, R-roscovitine)
Price: 10mg, $75, 50mg, $245; 100mg, $445; 200mg, $795
Dinaciclib (SCH 727965)
Dinaciclib (SCH 727965)
Price: 10mg, $275; 50mg, $895; 100mg, $1345; 200mg, $2195
SNS 032 (BMS 387032)
SNS 032 (BMS 387032)
Price: 10mg, $125; 50mg, $475; 100mg, $795; 200mg, $1095
AT 7519
AT 7519
Price: 10mg, $195; 50mg, $595; 100mg, $995; 200mg, $1695
PD 0332991
PD 0332991
Price: 10mg, $125; 50mg, $495; 100mg, $695; 200mg, $1095
LY-2835219
LY-2835219
Price: 100mg, $495; 500mg, $1495;
PHA 793887
PHA 793887
Price: 10mg, $225; 50mg, $695; 100mg, $895; 200mg, $1475