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Product name : GDC 0449 (Vismodegib, HhAntag691)
Item : cc580
Price : 10mg, $125; 50mg, $325; 100mg, $595; 200mg, $925
contact : Send inquiry to: info@acesobio.com,or by fax to: 1-845-673-1239.
Additional Information : We offer significant discount for bulky quantity order
CAS : 
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Details:
GDC-0449 (Vismodegib, HhAntag691) is a potent, novel and specific hedgehog pathway inhibitor with IC50 of 3 nM. Vismodegib targets the Hedgehog signaling pathway, blocking the activities of the Hedgehog-ligand cell surface receptors PTCH and/or SMO and suppressing Hedgehog signaling. The Hedgehog signaling pathway plays an important role in tissue growth and repair; aberrant constitutive activation of Hedgehog pathway signaling and uncontrolled cellular proliferation may be associated with mutations in the Hedgehog-ligand cell surface receptors PTCH and SMO. [1][2]
 
Reference:
[1] Trends Pharmacol. Sci. 2009, 30, 303-312.
[2] Clin. Cancer Res. 2011, 17, 4682-4692.
 
 
Chemical Information
Molecular Weight (WM):
421.30
Formula:
C19H14Cl2N2O3S
CAS No:
879085-55-9
Purity:
≥ 98%
Synonyms:
GDC 0449
 
DMSO ≥ 84 mg/mL
Solubility (25℃)
Water < 1 mg/mL
 
Ethanol ≥ 10 mg/mL
 
2 years     -20℃        Powder
Stability:
2 weeks     -4℃        in DMSO
 
2 months    -80℃       in DMSO
 
Quality control data:
Quality control by 1H-NMR, 13C-NMR, HPLC and LCMS.
Product will be shipped with supporting analytical data.
 
PLEASE KEEP THE PRODUCT UNDER -20℃ FOR LONG-TERM STORAGE.
 
NOT FOR HUMAN OR VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.

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