Apoptosis
Notch
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Product name : GDC 0449 (Vismodegib, HhAntag691)
Item : cc580
Price : 200mg, $459;500mg, $850; 1g $1195; 2g, $1795
contact : Send inquiry to: info@acesobio.com,or by fax to: 1-845-673-1239.
CAS : 879085-55-9
Molecular Weight : 421.3
Formula : C₁₉H₁₄Cl₂N₂O₃S
Storage : at -20°C
Additional information : We offer significant discount for bulky quantity order
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GDC-0449 (Vismodegib, HhAntag691) is a potent, novel and specific hedgehog pathway inhibitor with IC50 of 3 nM. Vismodegib targets the Hedgehog signaling pathway, blocking the activities of the Hedgehog-ligand cell surface receptors PTCH and/or SMO and suppressing Hedgehog signaling. The Hedgehog signaling pathway plays an important role in tissue growth and repair; aberrant constitutive activation of Hedgehog pathway signaling and uncontrolled cellular proliferation may be associated with mutations in the Hedgehog-ligand cell surface receptors PTCH and SMO. [1][2]
Reference:
[1] Trends Pharmacol. Sci. 2009, 30, 303-312.
[2] Clin. Cancer Res. 2011, 17, 4682-4692.
Chemical Information
PLEASE KEEP THE PRODUCT UNDER -20℃ FOR LONG-TERM STORAGE.
NOT FOR HUMAN OR VETERINARY DIAGNOSTIC OR THERAPEUTIC USE. |
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