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Product name : LY 411575
Item : cc581
Price : 200mg, $1250;500mg, $2090; 1g $2995; 2g, $4395
contact : Send inquiry to: info@acesobio.com,or by fax to: 1-845-673-1239.
CAS : 209984-57-6
Molecular Weight : 479.48
Formula : C₂₆H₂₃F₂N₃O₄
Storage : at -20°C
Additional information : We offer significant discount for bulky quantity order
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Details:
LY-411575 is a potent γ-secretase inhibitor as assessed by inhibition of Aβ production (IC50, 0.078 and 0.082 nM in membrane- and cell-based γ-secretase assays).  LY411575 is a selective, cell permeable, small molecule gamma secretase inhibitor which blocks Notch activation. Notch signaling is a pathway known to regulate both differentiation and proliferation of cells in diverse adult tissues. LY 411575 has been shown to promote goblet cell differentiation in mice intestine. Concurrently, LY411575 inhibits cell proliferation. LY411575 has also been observed to promote neural differentiation of mouse embryonic stem (ES) cells. [1][2]
 
Reference:
[1] Oncogene 2005, 24, 6333-6344.
[2] PLoS ONE 2009, 4, e6286.
 
 
Chemical Information
Molecular Weight (WM):
479.48
Formula:
C26H23F2N3O4
CAS No:
209984-57-6
Purity:
≥ 98%
Synonyms:
 
 
2 years     -20℃        Powder
Stability:
2 weeks     -4℃        in DMSO
 
2 months    -80℃       in DMSO
 
Quality control data:
Quality control by 1H-NMR, 13C-NMR, HPLC and LCMS.
Product will be shipped with supporting analytical data.
 
PLEASE KEEP THE PRODUCT UNDER -20℃ FOR LONG-TERM STORAGE.
 
NOT FOR HUMAN OR VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.

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