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Product name : RO 4929097
Item : cc19
Price : 10mg, $275; 50mg, $795; 100mg, $1295; 200mg, $2295
contact : Send inquiry to: info@acesobio.com,or by fax to: 1-845-673-1239.
Additional Information : We offer significant discount for bulky quantity order
CAS : 
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Details:
RO4929097 is an orally bioavailable γ secretase (GS) inhibitor with IC50 of 4 nM. RO-4929097 binds to GS and blocks activation of Notch receptors, which may inhibit tumor cell proliferation. The integral membrane protein GS is a multi-subunit protease complex that cleaves single-pass transmembrane proteins, such as Notch receptors, at residues within their transmembrane domains. Overexpression of the Notch signaling pathway has been correlated with increased tumor cell growth.  [1][2]
 
Reference:
[1] Cancer Res. 2009, 69, 7672-7680.
[2] Mol. Oncol. 2011, 5, 292-301.
 
 
Chemical Information
Molecular Weight (WM):
469.40
Formula:
C22H20F5N3O3
CAS No:
847925-91-1
Purity:
≥ 98%
Synonyms:
RO 4929097
 
DMSO ≥ 84 mg/mL
Solubility (25℃)
Water < 1 mg/mL
 
Ethanol ≥ 16 mg/mL
 
2 years     -20℃        Powder
Stability:
2 weeks     -4℃        in DMSO
 
2 months    -80℃       in DMSO
 
Quality control data:
Quality control by 1H-NMR, 13C-NMR, HPLC and LCMS.
Product will be shipped with supporting analytical data.
 
PLEASE KEEP THE PRODUCT UNDER -20℃ FOR LONG-TERM STORAGE.
 
NOT FOR HUMAN OR VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.

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