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Products > Neuro Signaling > Gama Secretase > Semagacestat (LY 450139)
Product name : Semagacestat (LY 450139)
Item : cc411
Price : 10mg, $225; 50mg, $695; 100mg, $895; 200mg, $1475
contact : Send inquiry to: info@acesobio.com,or by fax to: 1-845-673-1239.
Additional Information : We offer significant discount for bulky quantity order
CAS : 
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Details:
Semagacestat (LY450139) is a γ-secretase blocker of Aβ42, Aβ40 and Aβ38 with IC50 of 10.9 nM, 12.1 nM and 12.0 nM, respectively. Semagacestat (LY-450139) also inhibits Notch signaling with IC50 of 14.1 nM. Semagacestat blocks the enzyme γ-secretase, which (along with β-secretase) is responsible for APP proteolysis. β-Amyloid is formed by proteolysis of amyloid precursor protein (APP). Research on laboratory rats suggest that the soluble form of this peptide is a causative agent in the development of Alzheimer's.  [1][2]
 
Reference:
[1] J Neurosci. 2012, 32, 2037-2050.
[2] J Nerochem. 2009, 110, 1377-1387.
 
 
Chemical Information
Molecular Weight (WM):
361.44
Formula:
C19H27N3O4
CAS No:
425386-60-3, 866488-53-1
Purity:
≥ 98%
Synonyms:
LY 450139
 
DMSO ≥ 72 mg/mL
Solubility (25℃)
Water < 1 mg/mL
 
Ethanol ≥ 43 mg/mL
 
2 years     -20℃        Powder
Stability:
2 weeks     -4℃        in DMSO
 
2 months    -80℃       in DMSO
 
Quality control data:
Quality control by 1H-NMR, 13C-NMR, HPLC and LCMS.
Product will be shipped with supporting analytical data.
 
PLEASE KEEP THE PRODUCT UNDER -20℃ FOR LONG-TERM STORAGE.
 
NOT FOR HUMAN OR VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.

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