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Product name : TH 302
Item : cc588
Price : 10mg, $295; 50mg, $795; 100mg, $1295; 200mg, $1995
contact : Send inquiry to: info@acesobio.com,or by fax to: 1-845-673-1239.
Additional Information : We offer significant discount for bulky quantity order
CAS : 
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Details:
TH-302 is selective hypoxia-activated prodrug targeting hypoxic regions of solid tumors with IC50 of 19 nM. The 2-nitroimidazole moiety of hypoxia-activated prodrug TH302 acts as a hypoxic trigger, releasing the DNA-alkylating dibromo isophosphoramide mustard moiety within hypoxic regions of tumors. Normoxic tissues may be spared due to the hypoxia-specific activity of this agent, potentially reducing systemic toxicity.   [1][2]
 
Reference:
[1] J Med. Chem. 2008, 51, 2412-2420.
[2] Mol. Cancer Ther. 2012, 11, 740-741.
 
 
Chemical Information
Molecular Weight (WM):
449.04
Formula:
C9H16Br2N5O4P
CAS No:
918633-87-1
Purity:
≥ 98%
Synonyms:
TH 302
 
2 years     -20℃        Powder
Stability:
2 weeks     -4℃        in DMSO
 
2 months    -80℃       in DMSO
 
Quality control data:
Quality control by 1H-NMR, 13C-NMR, HPLC and LCMS.
Product will be shipped with supporting analytical data.
 
PLEASE KEEP THE PRODUCT UNDER -20℃ FOR LONG-TERM STORAGE.
 
NOT FOR HUMAN OR VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.

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