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Product name : PD 0325901
Item : cc-61
Price : 10mg, $110; 25mg, $250; 100mg, $695; 200mg, $975
contact : Send inquiry to: info@acesobio.com,or by fax to: 1-845-673-1239.
Additional Information : We offer significant discount for larger quantity order
CAS : 
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Details:
PD 0325901 is an orally bioavailable, synthetic organic molecule targeting mitogen-activated protein kinase kinase (MAPK/ERK kinase or MEK) with a Ki of 1 nM against activated MEK1 and MEK2. MEK inhibitor PD325901, a derivative of MEK inhibitor CI-1040, selectively binds to and inhibits MEK, which may result in the inhibition of the phosphorylation and activation of MAPK/ERK and the inhibition of tumor cell proliferation. The dual specific threonine/tyrosine kinase MEK is a key component of the RAS/RAF/MEK/ERK signaling pathway that is frequently activated in human tumors. [1][2]
Reference:
[1] Bioorg. Med. Chem. Lett. 2008, 18, 6501-6504.
[2] Proc. Amer. Assoc. Cancer Res. 2004, 45.
                                        
Chemical Information
Molecular Weight (WM):
482.193
Formula:
C16H14F3IN2O4
CAS No:
391210-10-9
Purity:
≥ 98%
Synonyms:
PD-0325901, PD0325901
 
DMSO ≥ 96 mg/mL
Solubility: (R.T.: 25℃):
Water < 1 mg/mL
 
Ethanol ≥ 96 mg/mL
 
2 years     -20℃        Powder
Stability:
2 weeks     -4℃        in DMSO
 
2 months    -80℃       in DMSO
 
Quality control data:
Quality control by 1H-NMR, 13C-NMR, HPLC and LCMS.
Product will be shipped with supporting analytical data.
 
PLEASE KEEP THE PRODUCT UNDER -20℃ FOR LONG-TERM STORAGE.
 
NOT FOR HUMAN OR VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.
 
 

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