Apoptosis
MNK
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Product name : PD 0325901
Item : cc-61
Price : 200mg, $650;500mg, $1050; 1g $1650; 2g, $2850
contact : Send inquiry to: info@acesobio.com,or by fax to: 1-845-673-1239.
CAS : 391210-10-9
Molecular Weight : 482.19
Formula : C₁₆H₁₄F₃IN₂O₄
Storage : at -20°C
Additional information : We offer significant discount for larger quantity order
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PD 0325901 is an orally bioavailable, synthetic organic molecule targeting mitogen-activated protein kinase kinase (MAPK/ERK kinase or MEK) with a Ki of 1 nM against activated MEK1 and MEK2. MEK inhibitor PD325901, a derivative of MEK inhibitor CI-1040, selectively binds to and inhibits MEK, which may result in the inhibition of the phosphorylation and activation of MAPK/ERK and the inhibition of tumor cell proliferation. The dual specific threonine/tyrosine kinase MEK is a key component of the RAS/RAF/MEK/ERK signaling pathway that is frequently activated in human tumors. [1][2]
Reference:
[1] Bioorg. Med. Chem. Lett. 2008, 18, 6501-6504.
[2] Proc. Amer. Assoc. Cancer Res. 2004, 45.
Chemical Information
PLEASE KEEP THE PRODUCT UNDER -20℃ FOR LONG-TERM STORAGE.
NOT FOR HUMAN OR VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.
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