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Products > Cell Cycle > PLK > HMN 214 (IVX 214)
Product name : HMN 214 (IVX 214)
Item : cc31
Price : 200mg, $950;500mg, $1595; 1g $2390; 2g, $3590
contact : Send inquiry to: info@acesobio.com,or by fax to: 1-845-673-1239.
CAS : 173529-46-9
Molecular Weight : 424.47
Formula : C₂₂H₂₀N₂O₅S
Storage : at -20°C
Additional information : We offer significant discount for bulky quantity order
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Details:
HMN-214 (IVX-214) is an oral and potent inhibitor to Polo-like kinase (Plk)1 with IC50 of 118 nM. HMN-214 is an oral prodrug that is rapidly converted to HMN-176. HMN-176 (2.5 μM) delays satisfaction of the spindle assembly checkpoint. HMN-176 (250 nM–2.5 μM) inhibits meiotic spindle assembly and aster formationin Spisula oocytes. HMN-176 (2.5 μM) also inhibits aster microtubule formation from human centrosomes. [1][2]
 
Reference:
[1] Cancer Res. 2003, 63, 6942-6947.
[2] Mol. Cancer Ther. 2009, 8, 592-601.
 
 
Chemical Information
Molecular Weight (WM):
424.47
Formula:
C22H20N2O5S
CAS No:
173529-46-9
Purity:
≥ 98%
Synonyms:
HMN214, IVX 214
 
DMSO ≥ 24 mg/mL
Solubility (25℃)
Water < 1 mg/mL
 
Ethanol < 1 mg/mL
 
2 years     -20℃        Powder
Stability:
2 weeks     -4℃        in DMSO
 
2 months    -80℃       in DMSO
 
Quality control data:
Quality control by 1H-NMR, 13C-NMR, HPLC and LCMS.
Product will be shipped with supporting analytical data.
 
PLEASE KEEP THE PRODUCT UNDER -20℃ FOR LONG-TERM STORAGE.
 
NOT FOR HUMAN OR VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.

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