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Product name : CHIR 98014
Item : cc83
Price : 200mg, $950;500mg, $1595; 1g $2390; 2g, $3590
contact : Send inquiry to: info@acesobio.com,or by fax to: 1-845-673-1239.
CAS : 252935-94-7
Molecular Weight : 486.31
Formula : C₂₀H₁₇Cl₂N₉O₂
Storage : at -20°C
Additional information : We offer significant discount for bulky quantity order
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Details:
CHIR-98014 is a potent and selective human GSK-3 inhibitor for human GSK-3ɑ and human GSK-3β with IC50 of 0.65 nM and 0.58 nM, respectively. Eeffects of GSK inhibitors on p-tau, GSK-3β activities and cell death were measured in a human neuronal cell line (LUHMES). CHIR98014 reduced tau phosphorylation (Ser396) in the cortex and hippocampus. Inhibition of GSK-3 is recently regarded as one of the viable approaches to therapy for Alzheimer’s disease, cancer, diabetes mellitus, osteoporosis, and bipolar mood disorder.  [1][2]
 
Reference:
[1] Diabetes 2003, 52, 588-595.
[2] Br. J Pharmacol. 2007, 152, 959-979.
 
 
Chemical Information
Molecular Weight (WM):
486.31
Formula:
C20H17Cl2N9O2
CAS No:
556813-39-9, 252935-94-7
Purity:
≥ 98%
Synonyms:
CHIR 98014
 
DMSO ≥ 15 mg/mL
Solubility (25℃)
Water < 1 mg/mL
 
Ethanol < 1 mg/mL
 
2 years     -20℃        Powder
Stability:
2 weeks     -4℃        in DMSO
 
2 months    -80℃       in DMSO
 
Quality control data:
Quality control by 1H-NMR, 13C-NMR, HPLC and LCMS.
Product will be shipped with supporting analytical data.
 
PLEASE KEEP THE PRODUCT UNDER -20℃ FOR LONG-TERM STORAGE.
 
NOT FOR HUMAN OR VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.

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