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Products > MAPK > Raf > SB 590885 (GSK 2118436, Dabrafenib)
Product name : SB 590885 (GSK 2118436, Dabrafenib)
Item : cc-3
Price : 10mg, $145; 50mg, $575; 100mg, $875; 200mg, $1595
contact : Send inquiry to: info@acesobio.com,or by fax to: 1-845-673-1239.
Additional Information : We offer significant discount for larger quantity order
CAS : 
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Details:
SB 590885 (GSK 2118436, Dabrafenib) is an orally bioavailable inhibitor of B-raf (BRAF) protein with a Ki app of 0.16 ± 0.03 nM. Dabrafenib selectively binds to and inhibits the activity of B-raf, which may inhibit the proliferation of tumor cells which contain a mutated BRAF gene. B-raf belongs to the the raf/mil family of serine/threonine protein kinases and plays a role in regulating the MAP kinase/ERKs signaling pathway, which may be constitutively activated due to BRAF gene mutations. [1]
 
Reference:
[1] Cancer Res. 2006, 66, 11100-11105.
                                        
Chemical Information
Molecular Weight (WM):
453.54
Formula:
C27H27N5O2
CAS No:
405554-55-4
Purity:
≥ 98%
Synonyms:
GSK-2188436, GSK2188436, SB590885
 
DMSO ≥ 16 mg/mL
Solubility: (R.T.: 25℃):
Water < 1 mg/mL
 
Ethanol < 1 mg/mL
 
2 years     -20℃        Powder
Stability:
2 weeks     -4℃        in DMSO
 
2 months    -80℃       in DMSO
 
Quality control data:
Quality control by 1H-NMR, 13C-NMR, HPLC and LCMS.
Product will be shipped with supporting analytical data.
 
PLEASE KEEP THE PRODUCT UNDER -20℃ FOR LONG-TERM STORAGE.
 
NOT FOR HUMAN OR VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.
 
 

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