Favorite  |  Set Home
Products > MAPK > Raf > GDC 0879
Product name : GDC 0879
Item : cc-213
Price : 10mg, $145; 50mg, $455; 100mg, $745; 200mg, $995
contact : Send inquiry to: info@acesobio.com,or by fax to: 1-845-673-1239.
Additional Information : We offer significant discount for larger quantity order
CAS : 
 Enlarge Image                   Back
←[Previous Product]              [Next Product]→


Details:
GDC-0879 is a highly selective, novel potent, orally bioavailable B-Raf inhibitor in various in vitro and cell-based assays with an IC50 estimate of 0.13 nM against purified B-Raf V600E enzyme and a cellular pERK IC50 of 63 nM in the MALME-3M cell line.For this compound, subnanomolar enzyme potency translated into very effective reduction of cellular viability of BRAF-mutant Malme3M cells (EC50 values were 0.75 umol/L for GDC-0879).In GDC-0879-treated mice, both cell line- and patient-derived BRAFV600E tumors exhibited stronger and more sustained pharmacodynamic inhibition (>90% for 8 hours) and improved survival compared with mutant KRAS-expressing tumors.   [1]
 
 
Reference:
[1] Cancer Res. 2009, 69, 3042-3051.

Chemical Information
Molecular Weight (WM):
334.37
Formula:
C19H18N4O2
CAS No:
905281-76-7
Purity:
≥ 98%
Synonyms:
GDC0879, GDC-0879
 
DMSO ≥ 67 mg/mL
Solubility: (R.T.: 25℃):
Water < 1 mg/mL
 
Ethanol ≥ 5 mg/mL
 
2 years     -20        Powder
Stability:
2 weeks     -4        in DMSO
 
2 months    -80       in DMSO
 
Quality control data:
Quality control by 1H-NMR, 13C-NMR, HPLC and LCMS.
Product will be shipped with supporting analytical data.
 
PLEASE KEEP THE PRODUCT UNDER -20 FOR LONG-TERM STORAGE.
 
NOT FOR HUMAN OR VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.

Related Products :
ZM 336372
ZM 336372
Price: 10mg, $95, 50mg, $295; 100mg, $545; 200mg, $995
GW 5074
GW 5074
Price: 5mg, $110; 50mg, $175; 150mg, $345
SB 590885 (GSK 2118436, Dabrafenib)
SB 590885 (GSK 2118436, Dabrafenib)
Price: 10mg, $145; 50mg, $575; 100mg, $875; 200mg, $1595
PLX 4032 (RG 7204, Zelboraf, RO 5185426)
PLX 4032 (RG 7204, Zelboraf, RO 5185426)
Price: 10mg, $60; 50mg, $245; 100mg, $450; 200mg; $695
LGX-818
LGX-818
Price: 50mg, $2945; 100mg, $4450
Dabrafenib (GSK 2118436)
Dabrafenib (GSK 2118436)
Price: 50mg, $195; 100mg, $395; 200mg, $695, 1g, $1295
Sorafenib (Nexavar)
Sorafenib (Nexavar)
Price: 10mg, $60; 50mg, $ 245; 100mg, $450; 200mg; $695
NVP-BHG712
NVP-BHG712
Price: 10mg, $275; 50mg, $725; 100mg, $1295; 200mg, $2295