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Product name : GDC 0879
Item : cc-213
Price : 200mg, $1350;500mg, $1950; 1g $2650; 2g, $3750
contact : Send inquiry to: info@acesobio.com,or by fax to: 1-845-673-1239.
CAS : 905281-76-7
Molecular Weight : 334.37
Formula : C₁₉H₁₈N₄O₂
Storage : at -20°C
Additional information : We offer significant discount for larger quantity order
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Details:
GDC-0879 is a highly selective, novel potent, orally bioavailable B-Raf inhibitor in various in vitro and cell-based assays with an IC50 estimate of 0.13 nM against purified B-Raf V600E enzyme and a cellular pERK IC50 of 63 nM in the MALME-3M cell line.For this compound, subnanomolar enzyme potency translated into very effective reduction of cellular viability of BRAF-mutant Malme3M cells (EC50 values were 0.75 umol/L for GDC-0879).In GDC-0879-treated mice, both cell line- and patient-derived BRAFV600E tumors exhibited stronger and more sustained pharmacodynamic inhibition (>90% for 8 hours) and improved survival compared with mutant KRAS-expressing tumors.   [1]
 
 
Reference:
[1] Cancer Res. 2009, 69, 3042-3051.

Chemical Information
Molecular Weight (WM):
334.37
Formula:
C19H18N4O2
CAS No:
905281-76-7
Purity:
≥ 98%
Synonyms:
GDC0879, GDC-0879
 
DMSO ≥ 67 mg/mL
Solubility: (R.T.: 25℃):
Water < 1 mg/mL
 
Ethanol ≥ 5 mg/mL
 
2 years     -20        Powder
Stability:
2 weeks     -4        in DMSO
 
2 months    -80       in DMSO
 
Quality control data:
Quality control by 1H-NMR, 13C-NMR, HPLC and LCMS.
Product will be shipped with supporting analytical data.
 
PLEASE KEEP THE PRODUCT UNDER -20 FOR LONG-TERM STORAGE.
 
NOT FOR HUMAN OR VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.

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