Favorite  |  Set Home
Products > Apoptosis > Farnesyltransferase > Lonafarnib (SCH 66336)
Product name : Lonafarnib (SCH 66336)
Item : cc590
Price : 10mg, $295; 50mg, $795; 100mg, $1295; 200mg, $1995
contact : Send inquiry to: info@acesobio.com,or by fax to: 1-845-673-1239.
Additional Information : We offer significant discount for bulky quantity order
CAS : 
 Enlarge Image                   Back
            


Details:
Lonafarnib (SCH66336) is a selectively farnesyl protein transferase (FPT) inhibitor of H-ras, K-ras-4B and N-ras with IC50 of 1.9 nM, 5.2 nM and 2.8 nM, respectively. Lonarfanib (SCH-66336) binds to and inhibits farnesyl transferase, an enzyme involved in the post-translational modification and activation of Ras proteins. Ras proteins participate in numerous signalling pathways (proliferation, cytoskeletal organization), and play an important role in oncogenesis. Mutated ras proteins have been found in a wide range of human cancers. [1][2]
 
Reference:
[1] Cancer Res. 1998, 58, 4947-4956.
[2] Cancer Res. 2003, 63, 4796-4800.
 
 
Chemical Information
Molecular Weight (WM):
638.82
Formula:
C27H31Br2ClN4O2
CAS No:
193275-84-2
Purity:
≥ 98%
Synonyms:
 
 
DMSO ≥ 127 mg/mL
Solubility (25℃)
Water < 1 mg/mL
 
Ethanol ≥ 127 mg/mL
 
2 years     -20℃        Powder
Stability:
2 weeks     -4℃        in DMSO
 
2 months    -80℃       in DMSO
 
Quality control data:
Quality control by 1H-NMR, 13C-NMR, HPLC and LCMS.
Product will be shipped with supporting analytical data.
 
PLEASE KEEP THE PRODUCT UNDER -20℃ FOR LONG-TERM STORAGE.
 
NOT FOR HUMAN OR VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.
 

Related Products :