Apoptosis
DHFR
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Product name : MS 275 (SNDX 275)
Item : cc216
Price : 200mg, $459;500mg, $850; 1g $1195; 2g, $1795
contact : Send inquiry to: info@acesobio.com,or by fax to: 1-845-673-1239.
CAS : 209783-80-2
Molecular Weight : 376.41
Formula : C₂₁H₂₀N₄O₃
Storage : at -20°C
Additional information : We offer significant discount for bulky quantity order
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MS-275 (SNDX-275) is a HDAC inhibitor of HDAC1 and HDAC3 with IC50 of 0.51 μM and 1.7 μM, respectively. MS275 (SNDX275) binds to and inhibits histone deacetylase, an enzyme that regulates chromatin structure and gene transcription. This agent appears to exert dose-dependent effects in human leukemia cells including cyclin-dependent kinase inhibitor 1A (p21/CIP1/WAF1)-dependent growth arrest and differentiation at low drug concentrations; a marked induction of reactive oxygen species (ROS); mitochondrial damage; caspase activation; and, at higher concentrations, apoptosis. In normal cells, cyclin-dependent kinase inhibitor 1A expression has been associated with cell-cycle exit and differentiation. [1][2]
Reference:
[1] Proc. Natl. Acad. Sci. USA 1999, 96, 4592-4597.
[2] Cancer Res. 2003, 63, 3637-3645.
Chemical Information
PLEASE KEEP THE PRODUCT UNDER -20℃ FOR LONG-TERM STORAGE.
NOT FOR HUMAN OR VETERINARY DIAGNOSTIC OR THERAPEUTIC USE. |
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