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Product name : Sorafenib (Nexavar)
Item : cc-333
Price : 10mg, $60; 50mg, $ 245; 100mg, $450; 200mg; $695
contact : Send inquiry to: info@acesobio.com,or by fax to: 1-845-673-1239.
Additional Information : We offer significant discount for larger quantity order
CAS : 
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Details:
Sorafenib is a novel, small molecular inhibitor of several tyrosine protein kinases (VEGFR and PDGFR) and RAF/MEK/ERK cascade inhibitor with an IC50 of 6, 22, 38 nM for Raf-1, wt BRAF and V599E mutant BRAF. Studies indicate that Sorafenib induces c-Raf phosphorylation at both Ser-43 and Ser-259. When combined with vitamin K1 phosphorylation is increased at these serine residues. Sorafenib also induces the phosphorylation of PKA. In addition, Sorafenib induces c-Met phosphorylation at Tyr-1349, which consequently induces PI3K-Akt phosphorylation. Studies determined that Sorafenib inhibits other kinases such as Flk-1 (vascular endothelial growth factor receptor 2, VEGFR2), platelet-derived growth factor receptor (PDGFR), FLT3, Ret, and c-Kit.[1][2]
 
Reference:
[1] Int. J Clin. Pharmacol. Ther. 2003, 41, 620-621.
[2] Bioorg. Med. Chem. Lett. 2004, 14, 783-786.
                                        
Chemical Information
Molecular Weight (WM):
637.03
Formula:
C21H16ClF3N4O3 ·C7H8O3S
CAS No:
475207-59-1, 284461-73-0
Purity:
≥ 98%
Synonyms:
Nexavar, BAY 43-9006
 
DMSO ≥ 127 mg/mL
Solubility: (R.T.: 25℃):
Water < 1 mg/mL
 
Ethanol < 1 mg/mL
 
2 years     -20℃        Powder
Stability:
2 weeks     -4℃        in DMSO
 
2 months    -80℃       in DMSO
 
Quality control data:
Quality control by 1H-NMR, 13C-NMR, HPLC and LCMS.
Product will be shipped with supporting analytical data.
 
PLEASE KEEP THE PRODUCT UNDER -20℃ FOR LONG-TERM STORAGE.
 
NOT FOR HUMAN OR VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.

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