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Product name : AP 24534 (Ponatinib)
Item : cc191
Price : 10mg, $95, 50mg, $295; 100mg, $495; 200mg, $695
contact : Send inquiry to: info@acesobio.com,or by fax to: 1-845-673-1239.
Additional Information : We offer significant discount for bulky quantity order
CAS : 
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Details:
AP24534 (Ponatinib) is a novel, potent multi-targeted inhibitor of Abl, PDGFRα, VEGFR2, FGFR1 and Src with IC50 of 0.37 nM, 1.1 nM, 1.5 nM, 2.2 nM and 5.4 nM, respectively. AP-24534 inhibits unmutated and all mutated forms of Bcr-Abl, including T315I, the highly drug therapy-resistant missense mutation of Bcr-Abl. AP 24534 also inhibits other tyrosine kinases including those associated with vascular endothelial growth factor receptors (VEGFRs) and fibroblast growth factor receptors (FGFRs); in addition, it inhibits the tyrosine kinase receptor TIE2 and FMS-related tyrosine kinase receptor-3 (Flt3). RTK inhibition by ponatinib hydrochloride may result in the inhibition of cellular proliferation and angiogenesis and may induce cell death. Bcr-Abl is a fusion tyrosine kinase encoded by the Philadelphia chromosome.  [1][2]
 
Reference:
[1] J Med. Chem. 2010, 53, 4701-4719.
[2] Mol. Cancer Ther. 2011, 10, 1028-1035.
 
  
Chemical Information
Molecular Weight (WM):
532.56
Formula:
C29H27F3N6O
CAS No:
943319-70-8, 1232836-25-7 (3HCl)
Purity:
≥ 98%
Synonyms:
 
 
DMSO ≥ 107 mg/mL
Solubility (25℃)
Water < 1 mg/mL
 
Ethanol ≥ 107 mg/mL
 
2 years     -20℃        Powder
Stability:
2 weeks     -4℃        in DMSO
 
2 months    -80℃       in DMSO
 
Quality control data:
Quality control by 1H-NMR, 13C-NMR, HPLC and LCMS.
Product will be shipped with supporting analytical data.
 
PLEASE KEEP THE PRODUCT UNDER -20℃ FOR LONG-TERM STORAGE.
 
NOT FOR HUMAN OR VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.

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