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Products > Receptor Tyrosine Kinase > VEGFR > ABT-869 (Linifanib, AL 39324)
Product name : ABT-869 (Linifanib, AL 39324)
Item : cc204
Price : 200mg, $950;500mg, $1595; 1g $2390; 2g, $3590
contact : Send inquiry to: info@acesobio.com,or by fax to: 1-845-673-1239.
CAS : 796967-16-3
Molecular Weight : 375.4
Formula : C₂₁H₁₈FN₅O
Storage : at -20°C
Additional information : We offer significant discount for bulky quantity order
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Details:
ABT-869 (Linifanib) is a novel, potent ATP-competitive RTK inhibitor of KDR, CSF-1R, Flt1 and Flt3 with IC50 of 4 nM, 3 nM, 3 nM and 3 nM, respectively. ABT869 inhibits members of the vascular endothelial growth factor (VEGF) and platelet-derived growth factor (PDGF) receptor families; it exhibits much less activity against unrelated RTKs, soluble tyrosine kinases, or serine/threonine kinases. ABT 869 does not have a general antiproliferative effect due to its high dose requirement. However, linifanib may exhibit potent antiproliferative and apoptotic effects on tumor cells whose proliferation is dependent on mutant kinases, such as fms-related tyrosine kinase receptor-3 (FLT3). [1][2]
 
Reference:
[1] Mol. Cancer Ther. 2006, 5, 995-1006.
[2] Mol. Cancer Ther. 2006, 5, 1007-1013.
 
  
Chemical Information
Molecular Weight (WM):
375.40
Formula:
C21H18FN5O
CAS No:
796967-16-3, 1145655-58-8 (HCl), 796967-17-4 (TFA)
Purity:
≥ 98%
Synonyms:
AL-39324, AL39324
 
DMSO ≥ 75 mg/mL
Solubility (25℃)
Water < 1 mg/mL
 
Ethanol ≥ 5 mg/mL
 
2 years     -20℃        Powder
Stability:
2 weeks     -4℃        in DMSO
 
2 months    -80℃       in DMSO
 
Quality control data:
Quality control by 1H-NMR, 13C-NMR, HPLC and LCMS.
Product will be shipped with supporting analytical data.
 
PLEASE KEEP THE PRODUCT UNDER -20℃ FOR LONG-TERM STORAGE.
 
NOT FOR HUMAN OR VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.
 

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