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Product name : AZ 628
Item : cc-82
Price : 200mg, $850;500mg, $1650; 1g $2250; 2g, $3450
contact : Send inquiry to: info@acesobio.com,or by fax to: 1-845-673-1239.
CAS : 878739-06-1
Molecular Weight : 451.52
Formula : C₂₇H₂₅N₅O₂
Storage : at -20°C
Additional information : We offer significant discount for larger quantity order
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Details:
AZ628 is a potent tyrosine protein inhibitor for wild-type CRAF and BRAF V600E with IC50 of 29 and 34 nM, respectively. AZ628 inhibits activities of preactivated wild-type B-Raf with an IC50 of 105, respectively. AZ628 also suppreses activities of a number of tyrosine protein kinases such as VEGFR2, DDR2, Lyn and Flt1, as well as FMS. AZ628 also prevents anchorage-dependent and -independent growth, gives rise to cell cycle arrest, and triggers apoptosis in colon and melanoma cell lines harboring B-RafV600E mutation.[1][2]
 
Reference:
[1] Expert Opin. Ther. Targets 2007, 11, 1587-1609.
[2] Nature 2010, 464, 431-435.
                                        
Chemical Information
Molecular Weight (WM):
451.52
Formula:
C27H25N5O2
CAS No:
878739-06-1
Purity:
≥ 98%
Synonyms:
AZ-628, AZ628
 
DMSO ≥ 90 mg/mL
Solubility: (R.T.: 25℃):
Water < 1 mg/mL
 
Ethanol < 1 mg/mL
 
2 years     -20℃        Powder
Stability:
2 weeks     -4℃        in DMSO
 
2 months    -80℃       in DMSO
 
Quality control data:
Quality control by 1H-NMR, 13C-NMR, HPLC and LCMS.
Product will be shipped with supporting analytical data.
 
PLEASE KEEP THE PRODUCT UNDER -20℃ FOR LONG-TERM STORAGE.
 
NOT FOR HUMAN OR VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.

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