Apoptosis
Aurora Kinase
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Product name : CCT 241533
Item : cc225
Price : 200mg, $1750;500mg, $2690; 1g $3590; 2g, $5190
contact : Send inquiry to: info@acesobio.com,or by fax to: 1-845-673-1239.
CAS : 1262849-73-9
Molecular Weight : 442.48
Formula : C₂₃H₂₇FN₄O₄
Storage : at -20°C
Additional information : We offer significant discount for bulky quantity order
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| Details: | |||||||||||||||||||
CCT241533 blocked CHK2 activity in human tumor cell lines in response to DNA damage. CHK2 is a checkpoint kinase involved in the ATM-mediated response to double-strand DNA breaks. Its potential as a drug target is still unclear, but inhibitors of CHK2 may increase the efficacy of genotoxic cancer therapies in a p53 mutant background by eliminating one of the checkpoints or DNA repair pathways contributing to cellular resistance. [1][2]
Reference:
[1] Cancer Res. 2011, 71, 463-472.
[2] J Med. Chem. 2011, 54, 580-590.
Chemical Information
PLEASE KEEP THE PRODUCT UNDER -20℃ FOR LONG-TERM STORAGE.
NOT FOR HUMAN OR VETERINARY DIAGNOSTIC OR THERAPEUTIC USE. |
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