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Product name : CCT 241533
Item : cc225
Price : 10mg, $295; 50mg, $795; 100mg, $1395; 200mg, $2395
contact : Send inquiry to: info@acesobio.com,or by fax to: 1-845-673-1239.
Additional Information : We offer significant discount for bulky quantity order
CAS : 
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Details:
CCT241533 blocked CHK2 activity in human tumor cell lines in response to DNA damage. CHK2 is a checkpoint kinase involved in the ATM-mediated response to double-strand DNA breaks. Its potential as a drug target is still unclear, but inhibitors of CHK2 may increase the efficacy of genotoxic cancer therapies in a p53 mutant background by eliminating one of the checkpoints or DNA repair pathways contributing to cellular resistance.  [1][2]
 
Reference:
[1] Cancer Res. 2011, 71, 463-472.
[2] J Med. Chem. 2011, 54, 580-590.
 
 
Chemical Information
Molecular Weight (WM):
442.48
Formula:
C23H27FN4O4
CAS No:
1262849-73-9
Purity:
≥ 98%
Synonyms:
CCT-241533
 
2 years     -20℃        Powder
Stability:
2 weeks     -4℃        in DMSO
 
2 months    -80℃       in DMSO
 
Quality control data:
Quality control by 1H-NMR, 13C-NMR, HPLC and LCMS.
Product will be shipped with supporting analytical data.
 
PLEASE KEEP THE PRODUCT UNDER -20℃ FOR LONG-TERM STORAGE.
 
NOT FOR HUMAN OR VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.

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