Favorite  |  Set Home
Products > Hormone > RAAS > Aliskiren
Product name : Aliskiren
Item : cc228
Price : 5mg, $275, 10mg, $475, 50mg, $1285, 100mg, $1995
contact : Send inquiry to: info@acesobio.com,or by fax to: 1-845-673-1239.
Additional Information : We offer significant discount for bulky quantity order
CAS : 
 Enlarge Image                   Back
             [Next Product]→


Details:
Aliskiren is a direct renin inhibitor with an IC50 of 0.72 nM against renin. Renin is the first enzyme in the renin-angiotensin-aldosterone system which plays a role in blood pressure control. Renin cleaves angiotensinogen to angiotensin I, which is in turn converted by (ACE) to angiotensin II. Angiotensin II has both direct and indirect effects on blood pressure. It directly causes arterial smooth muscle to contract, leading to vasoconstriction and increased blood pressure.   [1][2]
 
Reference:
[1] Circulation 2005, 111, 1012-1018.
[2] Lancet 2006, 368, 1449-1456.
 
 
Chemical Information
Molecular Weight (WM):
551.76
Formula:
C30H53N3O6
CAS No:
173334-58-2, 173334-57-1 (free base), 173399-03-6 (HCl)
Purity:
≥ 98%
Synonyms:
 
 
DMSO ≥ 122 mg/mL
Solubility (25℃)
Water ≥ 122 mg/mL
 
Ethanol ≥ 122 mg/mL
 
2 years     -20℃        Powder
Stability:
2 weeks     -4℃        in DMSO
 
2 months    -80℃       in DMSO
 
Quality control data:
Quality control by 1H-NMR, 13C-NMR, HPLC and LCMS.
Product will be shipped with supporting analytical data.
 
PLEASE KEEP THE PRODUCT UNDER -20℃ FOR LONG-TERM STORAGE.
 
NOT FOR HUMAN OR VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.
 

Related Products :
Rosuvastatin (Crestor)
Rosuvastatin (Crestor)
Price: 50mg, $295; 100mg, $495; 200mg, $795, 1g, $1295