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Products > Receptor Tyrosine Kinase > FGFR > BGJ 398 (NVP-BGJ398)
Product name : BGJ 398 (NVP-BGJ398)
Item : cc248
Price : 200mg, $459;500mg, $850; 1g $1195; 2g, $1795
contact : Send inquiry to: info@acesobio.com,or by fax to: 1-845-673-1239.
CAS : 872511-34-7
Molecular Weight : 560.48
Formula : C₂₆H₃₁Cl₂N₇O₃
Storage : at -20°C
Additional information : We offer significant discount for bulky quantity order
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Details:
BGJ398 (NVP-BGJ398) is a potent and selective fibroblast growth factor receptor family inhibitor for FGFR1, FGFR2, FGFR3 and FGFR4 with IC50 of 0.9 nM, 1.4 nM, 1 nM and 60 nM, respectively. BGJ-398 selectively binds to and inhibits the activities of FGFRs, which may result in the inhibition of tumor angiogenesis and tumor cell proliferation, and the induction of tumor cell death. FGFRs are a family of receptor tyrosine kinases which may be upregulated in various tumor cell types and may be involved in tumor cell differentiation and proliferation, tumor angiogenesis, and tumor cell survival.  [1]
 
Reference:
[1] J Med. Chem. 2011, 54, 7066-7083.
 
  
Chemical Information
Molecular Weight (WM):
560.48
Formula:
C26H31Cl2N7O3
CAS No:
872511-34-7, 1310746-11-2 (H2O), 1310746-12-3 (methanesulfonate), 1310746-17-8 (acetate)
Purity:
≥ 98%
Synonyms:
BGJ 398
 
DMSO ≥ 2 mg/mL
Solubility (25℃)
Water < 1 mg/mL
 
Ethanol < 1 mg/mL
 
2 years     -20℃        Powder
Stability:
2 weeks     -4℃        in DMSO
 
2 months    -80℃       in DMSO
 
Quality control data:
Quality control by 1H-NMR, 13C-NMR, HPLC and LCMS.
Product will be shipped with supporting analytical data.
 
PLEASE KEEP THE PRODUCT UNDER -20℃ FOR LONG-TERM STORAGE.
 
NOT FOR HUMAN OR VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.
 

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