Favorite  |  Set Home
Products > Neuro Signaling > AchR > PNU 120596
Product name : PNU 120596
Item : cc255
Price : 200mg, $950;500mg, $1595; 1g $2390; 2g, $3590
contact : Send inquiry to: info@acesobio.com,or by fax to: 1-845-673-1239.
CAS : 501925-31-1
Molecular Weight : 311.72
Formula : C₁₃H₁₄ClN₃O₄
Storage : at -20°C
Additional information : We offer significant discount for bulky quantity order
 Enlarge Image                   Back
←[Previous Product]              [Next Product]→


Details:
PNU-120596 is a positive allosteric modulator of the α7 nAChR with EC50 of 216 nM in α7*-expressing SH-EP1 cells. PNU120596 increases the frequency of ACh-evoked GABAergic postsynaptic currents in pyramidal neurons, which can be suppressed by TTX. In addition, studies show that PNU 120596 increases the average time the channel of nAChR is open, but does not have any effect on the selectivity of ions flowing through the channel. Furthermore, PNU 120596 has little effect on α4β2, α3β4 and α9α10 receptors. [1][2]
 
Reference:
[1] J Neurosci. 2005, 25, 4396-4405.
[2] Mol. Pharmacol. 2009, 76, 253-263.
 
 
Chemical Information
Molecular Weight (WM):
311.72
Formula:
C13H14ClN3O4
CAS No:
501925-31-1
Purity:
≥ 98%
Synonyms:
 
 
DMSO ≥ 62 mg/mL
Solubility (25℃)
Water < 1 mg/mL
 
Ethanol ≥ 1 mg/mL
 
2 years     -20℃        Powder
Stability:
2 weeks     -4℃        in DMSO
 
2 months    -80℃       in DMSO
 
Quality control data:
Quality control by 1H-NMR, 13C-NMR, HPLC and LCMS.
Product will be shipped with supporting analytical data.
 
PLEASE KEEP THE PRODUCT UNDER -20℃ FOR LONG-TERM STORAGE.
 
NOT FOR HUMAN OR VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.

Related Products :
Tolterodine tartrate (Deltol LA)
Tolterodine tartrate (Deltol LA)
Price: 200mg, $449;500mg, $850; 1g $1195; 2g, $1795
Fesoterodine fumarate (Toviaz)
Fesoterodine fumarate (Toviaz)
Price: 200mg, $459;500mg, $850; 1g $1195; 2g, $1795
Cevimeline (AF 102B)
Cevimeline (AF 102B)
Price: 200mg, $950;500mg, $1695; 1g, $2490; 2g, $3590
Solifenacin (YM 905)
Solifenacin (YM 905)
Price: 1g, $650;2g, $1050; 5g $1650
Rivastigmine tartrate (Exelon)
Rivastigmine tartrate (Exelon)
Price: 1g, $650;2g, $1050; 5g $1650