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Product name : PHA 767491
Item : cc260
Price : 200mg, $659;500mg, $1050; 1g $1595; 2g, $2355
contact : Send inquiry to: info@acesobio.com,or by fax to: 1-845-673-1239.
CAS : 845714-00-3
Molecular Weight : 213.24
Formula : C₁₂H₁₁N₃O
Storage : at -20°C
Additional information : We offer significant discount for bulky quantity order
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Details:
PHA-767491 is a potent ATP-competitive dual Cdc7/Cdk9 inhibitor with IC50 of 10 nM and 34 nM, respectively. PHA767491 prevents initiation of DNA replication. PHA 767491 induces apoptosis in a p53-independent manner in vivo and Inhibits cell proliferation in a variety of human cell lines (IC50 ~ 0.86 - 5.87 μM). PHA-767491 also inhibits mitogen-activated protein kinase-activated protein kinase-2 (MK-2) (IC50 = 171 nM).  [1][2]
 
Reference:
[1] J Med. Chem. 2007, 50, 2647-2654.
[2] Nature Chem. Biol. 2008, 4, 357.
 
  
Chemical Information
Molecular Weight (WM):
213.24
Formula:
C12H11N3O
CAS No:
845714-00-3, 942425-68-5 (HCl)
Purity:
≥ 98%
Synonyms:
 
 
DMSO ≥ 24 mg/mL
Solubility (25℃)
Water < 1 mg/mL
 
Ethanol < 1 mg/mL
 
2 years     -20℃        Powder
Stability:
2 weeks     -4℃        in DMSO
 
2 months    -80℃       in DMSO
 
Quality control data:
Quality control by 1H-NMR, 13C-NMR, HPLC and LCMS.
Product will be shipped with supporting analytical data.
 
PLEASE KEEP THE PRODUCT UNDER -20℃ FOR LONG-TERM STORAGE.
 
NOT FOR HUMAN OR VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.

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