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Products > Apoptosis > MDM-2 > NSC 207895 (XI 006)
Product name : NSC 207895 (XI 006)
Item : cc262
Price : 200mg, $1250;500mg, $2090; 1g $2995; 2g, $4395
contact : Send inquiry to: info@acesobio.com,or by fax to: 1-845-673-1239.
CAS : 58131-57-0
Molecular Weight : 279.25
Formula : C11H13N5O4
Storage : at -20°C
Additional information : We offer significant discount for bulky quantity order
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Details:
NSC-207895 (XI-006) is a cell-permeable benzofuroxan compound that downregulates the p53 negative regulator MDMX protein level in MCF-7, LNCaP, and A549 cells (1 to 10 µM for 16 to 24 h) by suppressesing MDMX promoter transcription activity (IC50 = 2.5 µM in HT1080 cells), leading to enhanced p53 stabilization and activation. NSC207895 (XI006) is a great complement to MDM2 antagonist Nutlin-3 in growth inhibition and apoptosis induction of cancer cells that are more sensitive to MDMX than MDM2 inhibition. [1][2]
 
Reference:
[1] Mol. Cancer Ther. 2011, 10, 69-79.
[2] J Biomol. Screen 2008, 13, 795-803.
 
 
Chemical Information
Molecular Weight (WM):
279.25
Formula:
C11H13N5O4
CAS No:
58131-57-0
Purity:
≥ 98%
Synonyms:
 
 
DMSO ≥ 56 mg/mL
Solubility (25℃)
Water < 1 mg/mL
 
Ethanol < 1 mg/mL
 
2 years     -20℃        Powder
Stability:
2 weeks     -4℃        in DMSO
 
2 months    -80℃       in DMSO
 
Quality control data:
Quality control by 1H-NMR, 13C-NMR, HPLC and LCMS.
Product will be shipped with supporting analytical data.
 
PLEASE KEEP THE PRODUCT UNDER -20℃ FOR LONG-TERM STORAGE.
 
NOT FOR HUMAN OR VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.

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