Favorite  |  Set Home
Products > Aurora/Ksp > Aurora > PF 03814735
Product name : PF 03814735
Item : cc272
Price : 200mg, $1750;500mg, $2690; 1g $3590; 2g, $5190
contact : Send inquiry to: info@acesobio.com,or by fax to: 1-845-673-1239.
CAS : 942487-16-3
Molecular Weight : 474.48
Formula : C₂₃H₂₅F₃N₆O₂
Storage : at -20°C
Additional information : We offer significant discount for bulky quantity order
 Enlarge Image                   Back
←[Previous Product]              [Next Product]→


Details:
PF-03814735 is a novel, potent, orally bioavailable and reversible inhibitor of both Aurora1 and Aurora2 kinases with IC50 with 0.8 nM and 5 nM, respectively. PF03814735 binds to and inhibits Aurora kinases A and B, which may result in the inhibition of cellular division and proliferation in tumor cells that overexpress these kinases. Aurora kinases are serine-threonine kinases that play essential roles in mitotic checkpoint control during mitosis.   [1][2]
 
Reference:
[1] Mol. Cancer Ther. 2010, 9, 883-894.
[2] Mol. Cancer Ther. 2012, 11, 710-719.
 
 
Chemical Information
Molecular Weight (WM):
474.48
Formula:
C23H25F3N6O2
CAS No:
942487-16-3
Purity:
≥ 98%
Synonyms:
 
 
2 years     -20℃        Powder
Stability:
2 weeks     -4℃        in DMSO
 
2 months    -80℃       in DMSO
 
Quality control data:
Quality control by 1H-NMR, 13C-NMR, HPLC and LCMS.
Product will be shipped with supporting analytical data.
 
PLEASE KEEP THE PRODUCT UNDER -20℃ FOR LONG-TERM STORAGE.
 
NOT FOR HUMAN OR VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.

Related Products :
Hesperadin
Hesperadin
Price: 200mg, $750;500mg, $1350; 1g $1950; 2g, $3150
MK 5108 (VX 689)
MK 5108 (VX 689)
Price: 200mg, $1750;500mg, $2690; 1g $3590; 2g, $5190
GSK 1070916
GSK 1070916
Price: 200mg, $1350;500mg, $1950; 1g $2650; 2g, $3750
AMG 900
AMG 900
Price: 200mg, $1750;500mg, $2350; 1g $2950; 2g, $4150
CYC 116
CYC 116
Price: 200mg, $650;500mg, $1050; 1g $1650; 2g, $2850
MLN 8054
MLN 8054
Price: 200mg, $1250;500mg, $2350; 1g $2950; 2g, $3850
ENMD 2076
ENMD 2076
Price: 200mg, $1350;500mg, $1950; 1g $2650; 2g, $3750
PHA 680632
PHA 680632
Price: 200mg, $1750;500mg, $2350; 1g $2950; 2g, $4150