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Product name : PF 03814735
Item : cc272
Price : 10mg, $275; 50mg, $695; 100mg, $1295; 200mg, $2295
contact : Send inquiry to: info@acesobio.com,or by fax to: 1-845-673-1239.
Additional Information : We offer significant discount for bulky quantity order
CAS : 
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Details:
PF-03814735 is a novel, potent, orally bioavailable and reversible inhibitor of both Aurora1 and Aurora2 kinases with IC50 with 0.8 nM and 5 nM, respectively. PF03814735 binds to and inhibits Aurora kinases A and B, which may result in the inhibition of cellular division and proliferation in tumor cells that overexpress these kinases. Aurora kinases are serine-threonine kinases that play essential roles in mitotic checkpoint control during mitosis.   [1][2]
 
Reference:
[1] Mol. Cancer Ther. 2010, 9, 883-894.
[2] Mol. Cancer Ther. 2012, 11, 710-719.
 
 
Chemical Information
Molecular Weight (WM):
474.48
Formula:
C23H25F3N6O2
CAS No:
942487-16-3
Purity:
≥ 98%
Synonyms:
 
 
2 years     -20℃        Powder
Stability:
2 weeks     -4℃        in DMSO
 
2 months    -80℃       in DMSO
 
Quality control data:
Quality control by 1H-NMR, 13C-NMR, HPLC and LCMS.
Product will be shipped with supporting analytical data.
 
PLEASE KEEP THE PRODUCT UNDER -20℃ FOR LONG-TERM STORAGE.
 
NOT FOR HUMAN OR VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.

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