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Product name : Pemetrexed disodium (Alimta, LY 231514)
Item : cc282
Price : 10mg, $95, 50mg, $345; 100mg, $595; 200mg, $995
contact : Send inquiry to: info@acesobio.com,or by fax to: 1-845-673-1239.
Additional Information : We offer significant discount for bulky quantity order
CAS : 
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Details:
Pemetrexed disodium (Alimta, LY-231514) is a novel antifolate and antimetabolite for TS, DHFR, and GARFT with Ki of 1.3 nM, 7.2 nM and 65 nM, respectively. Pemetrexed binds to and inhibits the enzyme thymidylate synthase (TS) which catalyses the methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP), an essential precursor in DNA synthesis. [1][2]
 
Reference:
[1] Cancer Res. 1997, 57, 1116-1123.
[2] Clin. Cancer Res. 2000, 6, 1016-1023.
 
 
Chemical Information
Molecular Weight (WM):
471.37
Formula:
C20H19N5Na2O6
CAS No:
150399-23-8, 137281-23-3 (free base)
Purity:
≥ 98%
Synonyms:
LY231514
 
DMSO < 1 mg/mL
Solubility (25℃)
Water ≥ 94 mg/mL
 
Ethanol < 1 mg/mL
 
2 years     -20℃        Powder
Stability:
2 weeks     -4℃        in DMSO
 
2 months    -80℃       in DMSO
 
Quality control data:
Quality control by 1H-NMR, 13C-NMR, HPLC and LCMS.
Product will be shipped with supporting analytical data.
 
PLEASE KEEP THE PRODUCT UNDER -20℃ FOR LONG-TERM STORAGE.
 
NOT FOR HUMAN OR VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.

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