Apoptosis
Aurora Kinase
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Product name : Combretastatin A4
Item : cc322
Price : 200mg, $659;500mg, $1050; 1g $1595; 2g, $2355
contact : Send inquiry to: info@acesobio.com,or by fax to: 1-845-673-1239.
CAS : C₁₈H₂₀O₅
Molecular Weight : 316.35
Formula : C₁₈H₂₀O₅
Storage : at -20°C
Additional information : We offer significant discount for bulky quantity order
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Combretastatin A4, which binds to tubulin dimers and prevents microtubule polymerization, resulting in mitotic arrest and apoptosis in endothelial cells. In addition, this agent disrupts the engagement of the endothelial cell–specific junctional molecule vascular endothelial-cadherin (VE-cadherin) and so the activity of the VE-cadherin/β-catenin/Akt signaling pathway, which may result in the inhibition of endothelial cell migration and capillary tube formation. As a result of fosbretabulin's dual mechanism of action, the tumor vasculature collapses, resulting in reduced tumor blood flow and ischemic necrosis of tumor tissue. [1][2]
Reference:
[1] Invest. New Drugs 1996, 14, 131-137.
[2] Int. J Oncol. 2001, 19, 821-825.
Chemical Information
PLEASE KEEP THE PRODUCT UNDER -20℃ FOR LONG-TERM STORAGE.
NOT FOR HUMAN OR VETERINARY DIAGNOSTIC OR THERAPEUTIC USE. |
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