Favorite  |  Set Home
Products > Receptor Tyrosine Kinase > HER > Mubritinib (TAK 165)
Product name : Mubritinib (TAK 165)
Item : cc594
Price : 200mg, $750;500mg, $1190; 1g $1890; 2g, $2995
contact : Send inquiry to: info@acesobio.com,or by fax to: 1-845-673-1239.
CAS : 366017-09-6
Molecular Weight : 468.47
Formula : C₂₅H₂₃F₃N₄O₂
Storage : at -20°C
Additional information : We offer significant discount for bulky quantity order
 Enlarge Image                   Back
←[Previous Product]              [Next Product]→


Details:
Mubritinib (TAK165) is a potent inhibitor to ErbB2 with IC50 of 6 nM. Mubritinib (TAK-165) displays > 4000-fold selectivity over other tyrosine kinases, such as EGFR, FGFR, PDGFR, Jak1, Src and Blk. Mubritinib significantly blocks HER2 phosphorylation, leading to the downregulation of PI3K-Akt and MAPK pathway in cell line BT474 with high level of HER2.   [1][2]
 
Reference:
[1] Int. J Urol. 2006, 13, 587-592.
[2] Oncol. Rep. 2004, 11, 1273-1279.
 
Chemical Information
Molecular Weight (WM):
468.47
Formula:
C25H23F3N4O2
CAS No:
366017-09-6
Purity:
≥ 98%
Synonyms:
TAK 165
 
DMSO ≥ 25 mg/mL
Solubility (25℃)
Water < 1 mg/mL
 
Ethanol < 1 mg/mL
 
2 years     -20℃        Powder
Stability:
2 weeks     -4℃        in DMSO
 
2 months    -80℃       in DMSO
 
Quality control data:
Quality control by 1H-NMR, 13C-NMR, HPLC and LCMS.
Product will be shipped with supporting analytical data.
 
PLEASE KEEP THE PRODUCT UNDER -20℃ FOR LONG-TERM STORAGE.
 
NOT FOR HUMAN OR VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.

Related Products :
CP 724714
CP 724714
Price: 200mg, $950;500mg, $1595; 1g $2390; 2g, $3590
BMS 599626 (AC 480)
BMS 599626 (AC 480)
Price: 200mg, $750;500mg, $1190; 1g $1890; 2g, $2995
ARRY 380
ARRY 380
Price: 200mg, $659;500mg, $1050; 1g $1595; 2g, $2355
AZD 8931 (Momelotinib)
AZD 8931 (Momelotinib)
Price: 200mg, $750;500mg, $1190; 1g $1890; 2g, $2995