Product name : Mubritinib (TAK 165)
Item : cc594
Price : 200mg, $750;500mg, $1190; 1g $1890; 2g, $2995
contact : Send inquiry to: info@acesobio.com,or by fax to: 1-845-673-1239.
CAS : 366017-09-6
Molecular Weight : 468.47
Formula : C₂₅H₂₃F₃N₄O₂
Storage : at -20°C
Additional information : We offer significant discount for bulky quantity order
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Mubritinib (TAK165) is a potent inhibitor to ErbB2 with IC50 of 6 nM. Mubritinib (TAK-165) displays > 4000-fold selectivity over other tyrosine kinases, such as EGFR, FGFR, PDGFR, Jak1, Src and Blk. Mubritinib significantly blocks HER2 phosphorylation, leading to the downregulation of PI3K-Akt and MAPK pathway in cell line BT474 with high level of HER2. [1][2]
Reference:
[1] Int. J Urol. 2006, 13, 587-592.
[2] Oncol. Rep. 2004, 11, 1273-1279.
Chemical Information
PLEASE KEEP THE PRODUCT UNDER -20℃ FOR LONG-TERM STORAGE.
NOT FOR HUMAN OR VETERINARY DIAGNOSTIC OR THERAPEUTIC USE. |
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