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Product name : Mubritinib (TAK 165)
Item : cc594
Price : 10mg, $65; 50mg, $275; 100mg, $450; 200mg, $795
contact : Send inquiry to: info@acesobio.com,or by fax to: 1-845-673-1239.
Additional Information : We offer significant discount for bulky quantity order
CAS : 
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Details:
Mubritinib (TAK165) is a potent inhibitor to ErbB2 with IC50 of 6 nM. Mubritinib (TAK-165) displays > 4000-fold selectivity over other tyrosine kinases, such as EGFR, FGFR, PDGFR, Jak1, Src and Blk. Mubritinib significantly blocks HER2 phosphorylation, leading to the downregulation of PI3K-Akt and MAPK pathway in cell line BT474 with high level of HER2.   [1][2]
 
Reference:
[1] Int. J Urol. 2006, 13, 587-592.
[2] Oncol. Rep. 2004, 11, 1273-1279.
 
Chemical Information
Molecular Weight (WM):
468.47
Formula:
C25H23F3N4O2
CAS No:
366017-09-6
Purity:
≥ 98%
Synonyms:
TAK 165
 
DMSO ≥ 25 mg/mL
Solubility (25℃)
Water < 1 mg/mL
 
Ethanol < 1 mg/mL
 
2 years     -20℃        Powder
Stability:
2 weeks     -4℃        in DMSO
 
2 months    -80℃       in DMSO
 
Quality control data:
Quality control by 1H-NMR, 13C-NMR, HPLC and LCMS.
Product will be shipped with supporting analytical data.
 
PLEASE KEEP THE PRODUCT UNDER -20℃ FOR LONG-TERM STORAGE.
 
NOT FOR HUMAN OR VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.

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