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Product name : ARRY 380
Item : cc595
Price : 200mg, $659;500mg, $1050; 1g $1595; 2g, $2355
contact : Send inquiry to: info@acesobio.com,or by fax to: 1-845-673-1239.
CAS : 937263-43-9
Molecular Weight : 480.52
Formula : C₂₆H₂₄N₈O₂
Storage : at -20°C
Additional information : We offer significant discount for bulky quantity order
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Details:
ARRY-380 is an orally bioavailable, potent, selective, small-molecule tyrosine kinase HER2 inhibitor with an IC50 of 8 nM.ARRY380 selectively binds to and inhibits the phosphorylation of ErbB-2, which may prevent the activation of ErbB-2 signal transduction pathways, resulting in growth inhibition and death of ErbB-2-expressing tumor cells. ErbB-2 is overexpressed in a variety of cancers and plays an important role in cellular proliferation and differentiation.    [1][2]
 
Reference:
[1] Am. J Respir. Cell Mol. Biol. 2012, 46, 380-388.
[2] PCT Int. Appl. (2009), 121pp. CODEN: PIXXD2 WO 2009042618 A1 20090402.
 
 
Chemical Information
Molecular Weight (WM):
569.63
Formula:
C29H27N7O4S
CAS No:
937265-83-3
Purity:
≥ 98%
Synonyms:
ARRY 380
 
DMSO ≥ 114 mg/mL
Solubility (25℃)
Water < 1 mg/mL
 
Ethanol < 1 mg/mL
 
2 years     -20℃        Powder
Stability:
2 weeks     -4℃        in DMSO
 
2 months    -80℃       in DMSO
 
Quality control data:
Quality control by 1H-NMR, 13C-NMR, HPLC and LCMS.
Product will be shipped with supporting analytical data.
 
PLEASE KEEP THE PRODUCT UNDER -20℃ FOR LONG-TERM STORAGE.
 
NOT FOR HUMAN OR VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.

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