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Product name : Gefitinib
Item : cc596
Price : 5g, $650;10g, $1050; 20g $1650
contact : Send inquiry to: info@acesobio.com,or by fax to: 1-845-673-1239.
CAS : 184475-35-2
Molecular Weight : 446.9
Formula : C₂₂H₂₄ClFN₄O₃
Storage : at -20°C
Additional information : We offer significant discount for bulky quantity order
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Details:
Gefitinib (Iressa, ZD-1839) is an EGFR inhibitor for Tyr1173, Tyr992, Tyr1173 and Tyr992 in the NR6wtEGFR and NR6W cells with IC50 of 37 nM, 37nM, 26 nM and 57 nM, respectively. Gefitinib (ZD1839)  inhibits the catalytic activity of numerous tyrosine kinases including the epidermal growth factor receptor (EGFR), which may result in inhibition of tyrosine kinase-dependent tumor growth. Specifically, this agent competes with the binding of ATP to the tyrosine kinase domain of EGFR, thereby inhibiting receptor autophosphorylation and resulting in inhibition of signal transduction. Gefitinib may also induce cell cycle arrest and inhibit angiogenesis. [1][2]
 
Reference:
[1] Cancer Res. 2001, 61, 7184-7188.
[2] Br. J Cancer 2005, 93, 915-923.
 
 
Chemical Information
Molecular Weight (WM):
446.90
Formula:
C22H24ClFN4O3
CAS No:
184475-35-2, 184475-55-6 (HCl)
Purity:
≥ 98%
Synonyms:
ZD 1839
 
DMSO ≥ 89 mg/mL
Solubility (25℃)
Water < 1 mg/mL
 
Ethanol ≥ 11 mg/mL
 
2 years     -20℃        Powder
Stability:
2 weeks     -4℃        in DMSO
 
2 months    -80℃       in DMSO
 
Quality control data:
Quality control by 1H-NMR, 13C-NMR, HPLC and LCMS.
Product will be shipped with supporting analytical data.
 
PLEASE KEEP THE PRODUCT UNDER -20℃ FOR LONG-TERM STORAGE.
 
NOT FOR HUMAN OR VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.

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