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Product name : PF 04217903
Item : cc599
Price : 200mg, $659;500mg, $1050; 1g $1595; 2g, $2355
contact : Send inquiry to: info@acesobio.com,or by fax to: 1-845-673-1239.
CAS : 956905-27-4
Molecular Weight : 372.38
Formula : C₁₉H₁₆N₈O
Storage : at -20°C
Additional information : We offer significant discount for bulky quantity order
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Details:
PF-04217903 is a selective ATP-competitive c-Met inhibitor with IC50 of 4.8 nM. PF04217903 selectively binds to and inhibits c-Met, disrupting the c-Met signaling pathway, which may result in the inhibition of tumor cell growth, migration and invasion of tumor cells, and the induction of death in tumor cells expressing c-Met. c-Met, a receptor tyrosine kinase overexpressed or mutated in many tumor cell types, plays key roles in tumor cell proliferation, survival, invasion, metastasis, and tumor angiogenesis.   [1][2]
 
Reference:
[1] Cancer Res. 2010, 70, 10090-10100.
[2] Eur. J Cancer 2011, 47, 1231-1243.
 
 
Chemical Information
Molecular Weight (WM):
372.38
Formula:
C19H16N8O
CAS No:
956905-27-4, 956906-93-7 (methanesulfonate), 1159490-81-9 (HCl
Purity:
≥ 98%
Synonyms:
 
 
DMSO ≥ 75 mg/mL
Solubility (25℃)
Water < 1 mg/mL
 
Ethanol < 1 mg/mL
 
2 years     -20℃        Powder
Stability:
2 weeks     -4℃        in DMSO
 
2 months    -80℃       in DMSO
 
Quality control data:
Quality control by 1H-NMR, 13C-NMR, HPLC and LCMS.
Product will be shipped with supporting analytical data.
 
PLEASE KEEP THE PRODUCT UNDER -20℃ FOR LONG-TERM STORAGE.
 
NOT FOR HUMAN OR VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.

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